Everything about MPL

🧭 Start here: a 6-step reading path

1. Read the overview: MPLA 5-minute orientation
2. Skim a recent paper: Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesisInfluential work since 2022
3. Pick up a classic book: MPLS-enabled applicationsThe most-reprinted book on the subject
4. Read the landmark paper: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligandCited 1,097 times
5. Go sideways: PLA closely related topic
6. Go sideways: CPLA closely related topic

🏆 Landmark papers (most cited)

• Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

  Frederic J. de Sauvage, Philip E. Hass, Susan D. Spencer · 1994 · Nature · 1,097 citations

• Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

  Kenneth Kaushansky, Si Lok, Richard D. Holly · 1994 · Nature · 857 citations

• Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche

  Hiroki Yoshihara, Fumio Arai, Kentaro Hosokawa · 2007 · Cell Stem Cell · 759 citations

• Thrombocytopenia in c-mpl-deficient mice

  A. Gurney, K Carver-Moore, F. de Sauvage · 1994 · Science · 564 citations

• c-Mpl ligand is a humoral regulator of megakaryocytopoiesis

  Françoise Wendling, Eugene Maraskovsky, Najet Debili · 1994 · Nature · 534 citations

• Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

  WS Alexander, AW Roberts, NA Nicola · 1996 · Blood · 525 citations

• CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons

  A Tefferi, T L Lasho, C M Finke · 2014 · Leukemia · 481 citations

• Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1

  A Tefferi · 2010 · Leukemia · 454 citations

🆕 Influential since 2022

• Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis

  Naotaka Tsutsumi, Zahra Masoumi, Sophie C. James · 2023 · Cell · 56 citations

• PF4 activates the c-Mpl–Jak2 pathway in platelets

  Richard J. Buka, Samantha J. Montague, Luis A. Moran · 2024 · Blood · 48 citations

• Analysis of the MPL/GDL Interface: Impact of MPL Intrusion into the GDL Substrate

  Anne Berger, Yen-Chun Chen, Jacqueline Gatzemeier · 2023 · Journal of The Electrochemical Society · 31 citations

• The EFT bootstrap at finite MPL

  Carl Beadle, Giulia Isabella, Davide Perrone · 2025 · Journal of High Energy Physics · 23 citations

• An experimental study on PEMFC water management based on the synergistic interaction of flow field and MPL

  Mingyu Lou, Liang Chen, Kai Lu · 2024 · International Journal of Hydrogen Energy · 23 citations

📚 Books worth reading

• MPLS-enabled applicationsIna Minei · 2006
• GMPLS technologiesNaoaki Yamanaka · 2005
• Service automation and dynamic provisioning techniques in IP/MPLS environmentsChristian Jacquenet, Mohamed Boucadair · 2008
• MPLS fundamentalsLuc De Ghein · 2006
• MPLS for metropolitan area networksNam-Kee Tan · 2004
• Designing and implementing IP/MPLS-based Ethernet Layer 2 VPN servicesZhuo Xu · 2009
• MPLS-enabled applicationsIna Minei · 2005
• Selecting MPLS VPN ServicesChris Lewis, Steve Pickavance · 2006

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

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