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Everything about Isomorphous replacement
Isomorphous replacement (IR) is historically the most common approach to solving the phase problem in X-ray crystallography studies of proteins. For protein crystals this method is conducted by soaking the crystal of a sample to be analyzed with a heavy atom solution or co-crystallization with the heavy atom. The addition of the heavy atom (or ion) to the structure should not affect the crystal formation or unit cell dimensions in comparison to its native form, hence, they should be isomorphic. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Isomorphous replacementA 5-minute orientation
- Skim a recent paper: Lithium and rubidium extraction from potash feldspar and biotite concentrates: Alkali metal component separation via isomorphous replacement roastingInfluential work since 2022
- Pick up a classic book: Isomorphous replacement and superlattice structures in the plagioclase felsparsThe most-reprinted book on the subject
- Read the landmark paper: The treatment of errors in the isomorphous replacement methodCited 400 times
- Go sideways: Single-wavelength anomalous diffractionA closely related topic
- Go sideways: Multi-wavelength anomalous diffractionA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
The treatment of errors in the isomorphous replacement method
THE ISOMORPHOUS REPLACEMENT OF IRON BY ALUMINIUM IN SOIL GOETHITES
Enhancing Proton Conduction in a Metal–Organic Framework by Isomorphous Ligand Replacement
The structure of haemoglobin - IV. Sign determination by the isomorphous replacement method
A least-squares refinement method for isomorphous replacement
The extension of the isomorphous replacement method to include anomalous scattering measurements
The theory of the method of isomorphous replacement for protein crystals. I
The single isomorphous replacement method
🆕 Influential since 2022
Lithium and rubidium extraction from potash feldspar and biotite concentrates: Alkali metal component separation via isomorphous replacement roasting
On the origins of isomorphous replacement in protein crystallography
Solid-State Replacement in the Polyhedra of Cu2+, Ni2+, and Co2+ upon Dehydration/Rehydration Processes Associated with a Color Change in Three Isomorphous Materials with 5,5′-Indigodisulfonate
Selective extraction of Li and Mn from spent lithium-ion battery smelting slag: Insights from isomorphous replacement in minerals
Single-support serial isomorphous replacement phasing
📚 Books worth reading
- 📕Isomorphous replacement and superlattice structures in the plagioclase felsparsS. H. Chao · 1940
- 📕Genesis of iron-ores by isomorphous and pseudo-morphous replacement of limestone, etcKimball, James P. · 1891
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
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- Multi-wavelength anomalous diffraction Multi-wavelength anomalous diffraction (sometimes Multi-wavelength anomalous dispersion; abbreviated MAD) is a technique used in X-ray crystallography…
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- Anomalous X-ray scattering Anomalous X-ray scattering (AXRS or XRAS) is a non-destructive determination technique within X-ray diffraction that makes use of the anomalous dispersion…
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- Crystallography Crystallography is the branch of science devoted to the study of molecular and crystalline structure and properties. The word crystallography is derived…
- X-ray diffraction X-ray diffraction is a generic term for phenomena associated with changes in the direction of X-ray beams due to interactions with the electrons around…
- Johannes Martin Bijvoet Johannes Martin Bijvoet ForMemRS (23 January 1892, Amsterdam – 4 March 1980, Winterswijk) was a Dutch chemist and crystallographer at the van 't Hoff Laboratory…