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Everything about Hit selection
In high-throughput screening (HTS), one of the major goals is to select compounds with a desired size of inhibition or activation effects. A compound with a desired size of effects in an HTS screen is called a hit. The process of selecting hits is called hit selection. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Hit selectionA 5-minute orientation
- Skim a recent paper: Virtual Screening and Hit Selection of Natural Compounds as Acetylcholinesterase InhibitorsInfluential work since 2022
- Pick up a classic book: Tell No OneThe most-reprinted book on the subject
- Read the landmark paper: Statistical Tests of Neutrality of Mutations Against Population Growth, Hitchhiking and Background SelectionCited 5,948 times
- Go sideways: Strictly standardized mean differenceA closely related topic
- Go sideways: High-throughput screeningA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Statistical Tests of Neutrality of Mutations Against Population Growth, Hitchhiking and Background Selection
FAST‐TRACK: Integrating QTL mapping and genome scans towards the characterization of candidate loci under parallel selection in the lake whitefish (Coregonus clupeaformis)
Improved Statistical Methods for Hit Selection in High-Throughput Screening
Ligand efficiency as a guide in fragment hit selection and optimization
Median Absolute Deviation to Improve Hit Selection for Genome-Scale RNAi Screens
Robust Statistical Methods for Hit Selection in RNA Interference High-Throughput Screening Experiments
Assessing antibody and nanobody nativeness for hit selection and humanization with AbNatiV
Enhanced HTS Hit Selection via a Local Hit Rate Analysis
🆕 Influential since 2022
Virtual Screening and Hit Selection of Natural Compounds as Acetylcholinesterase Inhibitors
Machine intelligence-driven framework for optimized hit selection in virtual screening
Landscape features in single-objective continuous optimization: Have we hit a wall in algorithm selection generalization?
Hurewicz and Hurewicz-type star selection principles for hit-and-miss topology
Abstract 4919: AI-enabled hit selection of drug screening on human pancreatic cancer organoids
📚 Books worth reading
Tell No OneHarlan Coben · 2000
HairsprayScott Wittman, Marc Shaiman · 2002
The PromSaundra Mitchell · 2019
Humorous hits and how to hold an audienceGrenville Kleiser · 1908
Selections from Toby Keith 35 Biggest HitsToby Keith · 2008
Humorous Hits and How to Hold an Audience; a Collection of Short Selections, Stories, and Sketches for All OccasionsGrenville Kleiser · 2012
Select Editions--Volume 2 2002Laura E. Kelly, Nicholas Sparks · 2002- 📕The relationship of hitting ability in baseball to selected anatomical measurements and motor responsesLarry Lester Edlund · 1972
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Strictly standardized mean difference In statistics, the strictly standardized mean difference (SSMD) is a measure of effect size. It is the mean divided by the standard deviation of a difference…
- High-throughput screening High-throughput screening (HTS) is a method for scientific discovery especially used in drug discovery and relevant to the fields of biology, materials…
- C+-probability In statistics, a c+-probability is the probability that a contrast variable obtains a positive value. Using a replication probability, the c+-probability…
- Z-factor The Z-factor is a measure of statistical effect size. It has been proposed for use in high-throughput screening (HTS), where it is also known as Z-prime…
- Dual-flashlight plot In statistics, a dual-flashlight plot is a type of scatter-plot in which the standardized mean of a contrast variable (SMCV) is plotted against the mean…
- High throughput biology High throughput biology (or high throughput cell biology) is the use of automation equipment with classical cell biology techniques to address biological…
- High-content screening High-content screening (HCS), also known as high-content analysis (HCA) or cellomics, is a method that is used in biological research and drug discovery…
- Hit to lead Hit to lead (H2L) also known as lead generation is a stage in early drug discovery where small molecule hits from a high throughput screen (HTS) are evaluated…