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Everything about High-throughput screening
Drug discovery technique
High-throughput screening (HTS) is a method for scientific discovery especially used in drug discovery and relevant to the fields of biology, materials science and chemistry. Using robotics, data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to quickly conduct millions of chemical, genetic, or pharmacological tests. Through this process one can quickly recognize active compounds, antibodies, or genes that modulate a particular biomolecular pathway. The results of these experiments provide starting points for drug design and for understanding the noninteraction or role of a particular location. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: High-throughput screeningA 5-minute orientation
- Skim a recent paper: High-Throughput Computational Screening of Two-Dimensional SemiconductorsInfluential work since 2022
- Pick up a classic book: 3-D Cell-Based Biosensors in Drug Discovery ProgramsThe most-reprinted book on the subject
- Read the landmark paper: A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening AssaysCited 6,472 times
- Go sideways: Hit selectionA closely related topic
- Go sideways: Strictly standardized mean differenceA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🏆 Landmark papers (most cited)
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays
Novel trends in high-throughput screening
The Future of High-Throughput Screening
High-throughput screening for biocatalysts
Overview of High‐Throughput Screening
High-throughput screening
High Throughput Screening in Agrochemical Research
Virtual screening: a real screening complement to high-throughput screening
🆕 Influential since 2022
High-Throughput Computational Screening of Two-Dimensional Semiconductors
3D cell cultures toward quantitative high-throughput drug screening
Two-dimensional ferroelectrics from high throughput computational screening
Digital Barcodes for High-Throughput Screening
Widefield SERS for High‐Throughput Nanoparticle Screening
📚 Books worth reading
3-D Cell-Based Biosensors in Drug Discovery ProgramsWilliam S. Kisaalita · 2009
HighThroughput Screening Methods in Toxicity TestingPablo Steinberg · 2013
Management Of Chemical And Biological Samples For Screening ApplicationsMark Wigglesworth · 2012
A practical guide to assay development and high-throughput screening in drug discoveryTaosheng Chen · 2009
Applying Genomic and Proteomic Microarray Technology in Drug DiscoveryRobert S. Matson · 2004
Cell-based microarraysElla Palmer · 2011- 📕Drug Discovery ToxicologyYvonne Will, J. Eric McDuffie · 2016
- 📕Lead generation approaches in drug discoveryZoran Rankovic · 2010
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Hit selection In high-throughput screening (HTS), one of the major goals is to select compounds (including small molecules, siRNAs, shRNA, genes, et al.) with a desired…
- Strictly standardized mean difference In statistics, the strictly standardized mean difference (SSMD) is a measure of effect size. It is the mean divided by the standard deviation of a difference…
- Z-factor The Z-factor is a measure of statistical effect size. It has been proposed for use in high-throughput screening (HTS), where it is also known as Z-prime…
- C+-probability In statistics, a c+-probability is the probability that a contrast variable obtains a positive value. Using a replication probability, the c+-probability…
- High throughput biology High throughput biology (or high throughput cell biology) is the use of automation equipment with classical cell biology techniques to address biological…
- Compound management Compound management in the field of drug discovery refers to the systematic collection, storage, retrieval, and quality control of small molecule chemical…
- Hit to lead Hit to lead (H2L) also known as lead generation is a stage in early drug discovery where small molecule hits from a high throughput screen (HTS) are evaluated…
- High-content screening High-content screening (HCS), also known as high-content analysis (HCA) or cellomics, is a method that is used in biological research and drug discovery…