Everything about Genotype
Part of the genetic makeup of a cell which determines one of its characteristics
The genotype of an organism is its complete set of genetic material. Genotype can also be used to refer to the alleles or variants an individual carries in a particular gene or genetic location. The number of alleles an individual can have of a specific gene depends on the number of copies of each chromosome found in that species, also referred to as ploidy. In diploid species like humans, two full sets of chromosomes are present, meaning each individual has two alleles for any given gene. If both alleles are the same, the genotype is referred to as homozygous. If the alleles are different, the genotype is referred to as heterozygous. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: GenotypeA 5-minute orientation
- Skim a recent paper: The cancer-immunity cycle: Indication, genotype, and immunotypeInfluential work since 2022
- Pick up a classic book: Mapping human historyThe most-reprinted book on the subject
- Read the landmark paper: Inference of Population Structure Using Multilocus Genotype DataCited 24,342 times
- Go sideways: Classical geneticsA closely related topic
- Go sideways: Dominance (genetics)A closely related topic
📖 Definitions
Noun The part (DNA sequence) of the genetic makeup of an organism which determines a specific characteristic (phenotype) of that organism.
Noun A group of organisms having the same genetic constitution.
Verb To determine the genotype of.
Noun The type species of a genus; generitype.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Inference of Population Structure Using Multilocus Genotype Data
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
The Genotype-Tissue Expression (GTEx) project
Inference of Population Structure Using Multilocus Genotype Data: Linked Loci and Correlated Allele Frequencies
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade
Next-generation genotype imputation service and methods
🆕 Influential since 2022
The cancer-immunity cycle: Indication, genotype, and immunotype
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update
APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry
Betibeglogene Autotemcel Gene Therapy for Non–β 0 /β 0 Genotype β-Thalassemia
📚 Books worth reading
Mapping human historySteve Olson · 2002
GGE biplot analysisWeikai Yan, Manjit S. Kang · 2002- 📕Cells in Evolutionary BiologyBrian K. Hall, Sally A. Moody · 2018
Forensic DNA analysisJaiprakash G. Shewale, Ray H. Liu · 2013
PhenomicsJohn M. Hancock · 2014- 📕Genotype-By-Environment Interactions and Sexual SelectionJohn Hunt, David J. Hosken · 2014
MismatchSir Peter Gluckman, Mark Hanson · 2006
GenomeJerry E. Bishop · 1990
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Classical genetics Classical genetics is the branch of genetics based solely on visible results of reproductive acts. It is the oldest discipline in the field of genetics…
- Dominance (genetics) In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the effect of a different variant of the…
- Mendelian inheritance Mendelian inheritance (sometimes referred to as Mendelism) is a type of biological inheritance following the principles originally proposed by Gregor Mendel…
- Hereditary carrier A hereditary carrier (genetic carrier or just carrier) is a person or other organism that has inherited a recessive allele for a genetic trait or mutation…
- Allele An allele (UK: /ˈæliːl, əˈliːl/) is a variant of the sequence of nucleotides at a particular location, or locus, on a DNA molecule. Alleles can differ…
- Human genetics Human genetics is the study of inheritance as it occurs in human beings. Human genetics encompasses a variety of overlapping fields including: classical…
- Test cross Under the law of dominance in genetics, an individual expressing a dominant phenotype could contain either two copies of the dominant allele (homozygous…
- Punnett square The Punnett square is a square diagram that is used to predict the genotypes of a particular cross or breeding experiment. It is named after Reginald C…