Everything about GAS6

🧭 Start here: a 6-step reading path

1. Read the overview: GAS6A 5-minute orientation
2. Skim a recent paper: Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion proteinInfluential work since 2022
3. Pick up a classic book: Health care and poor relief in 18th and 19th century northern EuropeThe most-reprinted book on the subject
4. Read the landmark paper: The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinasesCited 642 times
5. Go sideways: TYRO3A closely related topic
6. Go sideways: AXL receptor tyrosine kinaseA closely related topic

🏆 Landmark papers (most cited)

• The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases

  Trevor N Stitt, Greg Conn, Martin Goret · 1995 · Cell · 642 citations

• Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis

  Anne Angelillo-Scherrer, Pablo Garcia de Frutos, Cristina Aparicio · 2001 · Nature Medicine · 375 citations

• TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis

  Jonathan H. M. van der Meer, Tom van der Poll, Cornelis van ‘t Veer · 2014 · Blood · 323 citations

• Gas6 and protein S

  Sassan Hafizi, Björn Dahlbäck · 2006 · The FEBS Journal · 318 citations

• The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.

  G Manfioletti, C Brancolini, G Avanzi · 1993 · Molecular and Cellular Biology · 314 citations

• GAS6/AXL Axis Regulates Prostate Cancer Invasion, Proliferation, and Survival in the Bone Marrow Niche

  Yusuke Shiozawa, Elisabeth A. Pedersen, Lalit R. Patel · 2010 · Neoplasia · 296 citations

• Structural basis for Gas6–Axl signalling

  Takako Sasaki, Pjotr G Knyazev, Naomi J Clout · 2005 · The EMBO Journal · 275 citations

• Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET

  Erinn B. Rankin, Katherine C. Fuh, Laura Castellini · 2014 · Proceedings of the National Academy of Sciences · 256 citations

🆕 Influential since 2022

• Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein

  Hyuncheol Jung, Se Young Lee, Seongjoon Lim · 2022 · Nature Medicine · 95 citations

• Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis

  Gaia Bellomo, Carolyn Rainer, Valeria Quaranta · 2022 · Gut · 89 citations

• Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

  Zihao Yao, Weizhong Qi, Hongbo Zhang · 2023 · eLife · 87 citations

• Gas6/AXL pathway: immunological landscape and therapeutic potential

  Xiaoqian Zhai, Dan Pu, Rulan Wang · 2023 · Frontiers in Oncology · 51 citations

• Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice

  Junjia Tang, Yichao Jin, Feng Jia · 2022 · Translational Stroke Research · 49 citations

📚 Books worth reading

• Health care and poor relief in 18th and 19th century northern EuropeOle Peter Grell, Cunningham, Andrew Dr · 2002
• Medieval and early Renaissance medicineNancy G. Siraisi · 1990
• Caspian Pipelines (Former Soviet South Papers, 2nd Series)John Roberts · 1996
• The XXVI OlympiadCarl A. Posey · 2000

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• TYRO3 Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene. TYRO3 has been shown to interact with: GAS6, and PIK3R1…
• AXL receptor tyrosine kinase Tyrosine-protein kinase receptor UFO is a protein that in human is encoded by the AXL gene. The gene was initially designated as UFO, in allusion to the…
• MERTK Proto-oncogene tyrosine-protein kinase MER is an enzyme that in humans is encoded by the MERTK gene. This gene is a member of the TYRO3/AXL/MER (TAM) receptor…
• Decoy receptors A decoy receptor is a receptor that is able to recognize and bind specific ligands efficiently, but is not able to support its intended function. This…
• ERBB4 Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced variants that encode different…
• Angiopoietin-1 receptor Angiopoietin-1 receptor is an angiopoietin receptor protein that in humans is encoded by the TEK gene. TEK is also known as TEK tyrosine kinase, TIE2 and…
• TNK2 Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. TNK2 gene encodes a non-receptor tyrosine kinase…
• Receptor tyrosine kinase Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique…