Everything about Exogenous DNA
DNA originating from outside an organism
Exogenous DNA is DNA originating outside the organism of concern or study. Exogenous DNA can be found naturally in the form of partially degraded fragments left over from dead cells. These DNA fragments may then become integrated into the chromosomes of nearby bacterial cells to undergo mutagenesis. This process of altering bacteria is known as transformation. Bacteria may also undergo artificial transformation through chemical and biological processes. The introduction of exogenous DNA into eukaryotic cells is known as transfection. Exogenous DNA can also be artificially inserted into the genome, which revolutionized the process of genetic modification in animals. By microinjecting an artificial transgene into the nucleus of an animal embryo, the exogenous DNA is allowed to merge the cell's existing DNA to create a genetically modified, transgenic animal. The creation of transgenic animals also leads into the study of altering sperm cells with exogenous DNA. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Exogenous DNAA 5-minute orientation
- Skim a recent paper: Transition metal complexes as self-activating chemical nucleases: proficient DNA cleavage without any exogenous redox agentsInfluential work since 2022
- Pick up a classic book: Principles of gene manipulation and genomicsThe most-reprinted book on the subject
- Read the landmark paper: The interaction between exogenous DNA and sperm cellsCited 90 times
- Go sideways: TransgeneA closely related topic
- Go sideways: Genetic engineering techniquesA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
The interaction between exogenous DNA and sperm cells
Uptake of exogenous DNA by plant protoplasts
Introduction of exogenous DNA into Chlamydomonas reinhardtii by electroporation.
Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates
Uptake of exogenous DNA by mammalian spermatozoa: specific localization of DNA on sperm heads
Fate of Exogenous DNA in Arabidopsis thaliana
BAF is a cytosolic DNA sensor that leads to exogenous DNA avoiding autophagy
Spontaneous uptake of exogenous DNA by bull spermatozoa
🆕 Influential since 2022
Transition metal complexes as self-activating chemical nucleases: proficient DNA cleavage without any exogenous redox agents
Exogenous glutathione can alleviate chromium toxicity in kenaf by activating antioxidant system and regulating DNA methylation
Exogenous azacytidine alleviates peel browning of postharvest bananas (Musa acuminata) showing an important role of DNA methylation
DNA damage-inducing endogenous and exogenous factors and research progress
Exogenous and endogenous formaldehyde-induced DNA damage in the aging brain: mechanisms and implications for brain diseases
📚 Books worth reading
Principles of gene manipulation and genomicsS. B. Primrose · 2006
NeurogeneticsNicholas T. Potter · 2003
MicroinjectionDavid J. Carroll · 2009
Rat genomicsIgnacio Anegon · 2010- 📕Free radicals and antioxidants in nutritionSebastiano Banni, Catherine Rice-Evans · 1993
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Transgene A transgene is a gene that has been transferred naturally, or by any of a number of genetic engineering techniques, from one organism to another. The introducti…
- Genetic engineering techniques Genetic engineering techniques allow the modification of animal and plant genomes. Techniques have been devised to insert, delete, and modify DNA at multiple…
- Gene delivery Gene delivery is the process of introducing foreign genetic material, such as DNA or RNA, into host cells. Gene delivery must reach the genome of the host…
- Sperm-mediated gene transfer Sperm-mediated gene transfer (SMGT) is a transgenic technique that transfers genes based on the ability of sperm cells to spontaneously bind to and internalize…
- Gene gun In genetic engineering, a gene gun or biolistic particle delivery system is a device used to deliver exogenous DNA (transgenes), RNA, or protein to cells…
- Transgenesis Transgenesis is the process of introducing an exogenous gene—called a transgene—into a living organism so that the organism will exhibit a new property…
- Genetically modified animal Genetically modified animals are animals that have been genetically modified for a variety of purposes including producing drugs, enhancing yields, increasing…
- Genetic transformation In molecular biology and genetics, transformation is the genetic alteration of a bacterial cell resulting from the direct uptake and incorporation of exogenous…