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Everything about Diploidization

Change in a genome

Diploidization is the process of converting a polyploid genome back into a diploid one. This can happen both with autopolyploidy due to whole genome duplication (WGD) or allopolyploidy due to hybridization. In any case, the genome instability acts as an evolutionary pressure to coax the genome back to a (functionally) diploid state, both in terms of gene dosage and in terms of pairing behavior during cell division. This is often achieved by losing large segments. Wikipedia →

🧭 Start here: a 6-step reading path

  1. Read the overview: DiploidizationA 5-minute orientation
  2. Skim a recent paper: Genomic Insights into Genetic Diploidization in the Homosporous Fern Adiantum nelumboidesInfluential work since 2022
  3. Pick up a classic book: Transformation of human diploid fibroblastsThe most-reprinted book on the subject
  4. Read the landmark paper: Gene duplication and evolution in recurring polyploidization–diploidization cycles in plantsCited 1,078 times
  5. Go sideways: PolyploidyA closely related topic
  6. Go sideways: PaleopolyploidyA closely related topic

📖 Definitions

Noun The repeated loss of chromosomes by a tetraploid organism to become diploid

🗂️ The subject at a glance

  1. Drive for diploidization
  2. Revolutionary vs. evolutionary changes
  3. Mechanisms
  4. Results
  5. Further consequences

🏆 Landmark papers (most cited)

🆕 Influential since 2022

📚 Books worth reading

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics