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Everything about DUSP4
Protein-coding gene in the species Homo sapiens
Dual specificity protein phosphatase 4 is an enzyme that in humans is encoded by the DUSP4 gene. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: DUSP4A 5-minute orientation
- Skim a recent paper: Genome-Wide CRISPR/Cas9 Library Screening Identified that DUSP4 Deficiency Induces Lenvatinib Resistance in Hepatocellular CarcinomaInfluential work since 2022
- Read the landmark paper: Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistanceCited 236 times
- Go sideways: DUSP1A closely related topic
- Go sideways: DUSP6A closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance
An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers
Mutated KRAS results in overexpression of DUSP4, a MAP‐kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas
Activation of MAPK Pathways due to DUSP4 Loss Promotes Cancer Stem Cell-like Phenotypes in Basal-like Breast Cancer
Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition
MiR-122-5p inhibits cell migration and invasion in gastric cancer by down-regulating DUSP4
Inhibition of Gluconeogenesis through Transcriptional Activation of EGR1 and DUSP4 by AMP-activated Kinase
🆕 Influential since 2022
Genome-Wide CRISPR/Cas9 Library Screening Identified that DUSP4 Deficiency Induces Lenvatinib Resistance in Hepatocellular Carcinoma
DUSP4 promotes esophageal squamous cell carcinoma progression by dephosphorylating HSP90β
DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF
ARID1A loss activates MAPK signaling via DUSP4 downregulation
DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response
📚 Books worth reading
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🔗 Related topics
- DUSP1 Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene. The expression of DUSP1 gene is induced in human skin…
- DUSP6 Dual specificity phosphatase 6 (DUSP6) is a phosphatase enzyme that is encoded by the DUSP6 gene in humans. DUSP6 is a member of the dual specificity protein…
- MAPK phosphatase MAPK phosphatases (MKPs) are the largest class of phosphatases involved in down-regulating Mitogen-activated protein kinases (MAPK) signaling. MAPK signalling…
- DUSP19 Dual specificity protein phosphatase 19 is an enzyme that in humans is encoded by the DUSP19 gene. DUSP19 has been shown to interact with ASK1 and MAP2K7…
- DUSP2 Dual specificity protein phosphatase 2 is an enzyme that in humans is encoded by the DUSP2 gene. The protein encoded by this gene is a member of the dual…
- DUSP16 Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene. The activation of mitogen-activated protein kinase (MAPK)…
- DUSP5 Dual specificity protein phosphatase 5 is an enzyme that in humans is encoded by the DUSP5 gene. The protein encoded by this gene is a member of the dual…
- DUSP10 Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene. Dual specificity protein phosphatases inactivate their…