Everything about DCL4

🧭 Start here: a 6-step reading path

1. Read the overview: DCL4A 5-minute orientation
2. Skim a recent paper: The dicing activity of DCL3 and DCL4 is negatively affected by flavonoidsInfluential work since 2022
3. Pick up a classic book: Journal of the American Oriental SocietyThe most-reprinted book on the subject
4. Read the landmark paper: Partially Redundant Functions of Arabidopsis DICER-like Enzymes and a Role for DCL4 in Producing trans-Acting siRNAsCited 556 times
5. Go sideways: Trans-acting siRNAA closely related topic
6. Go sideways: DCL2A closely related topic

🏆 Landmark papers (most cited)

• Partially Redundant Functions of Arabidopsis DICER-like Enzymes and a Role for DCL4 in Producing trans-Acting siRNAs

  Virginie Gasciolli, Allison C. Mallory, David P. Bartel · 2005 · Current Biology · 556 citations

• An antagonistic function for Arabidopsis DCL2 in development and a new function for DCL4 in generating viral siRNAs

  Nicolas Bouché, Dominique Lauressergues, Virginie Gasciolli · 2006 · The EMBO Journal · 472 citations

• Arabidopsis DRB4, AGO1, AGO7, and RDR6 participate in a DCL4-initiated antiviral RNA silencing pathway negatively regulated by DCL1

  Feng Qu, Xiaohong Ye, T. Jack Morris · 2008 · Proceedings of the National Academy of Sciences · 382 citations

• Roles of DCL4 and DCL3b in rice phased small RNA biogenesis

  Xianwei Song, Pingchuan Li, Jixian Zhai · 2011 · The Plant Journal · 309 citations

• The dsRNA-binding protein DRB4 interacts with the Dicer-like protein DCL4 in vivo and functions in the trans-acting siRNA pathway

  Yukihiro Nakazawa, Akihiro Hiraguri, Hiromitsu Moriyama · 2007 · Plant Molecular Biology · 125 citations

• Structure of the Arabidopsis thaliana DCL4 DUF283 domain reveals a noncanonical double-stranded RNA-binding fold for protein–protein interaction

  Haina Qin, Fading Chen, Xuelu Huan · 2010 · RNA · 99 citations

• Distinct substrate specificities of Arabidopsis DCL3 and DCL4

  Hideaki Nagano, Akihito Fukudome, Akihiro Hiraguri · 2013 · Nucleic Acids Research · 92 citations

• DCL4 Targets Cucumber Mosaic Virus Satellite RNA at Novel Secondary Structures

  Quan-Sheng Du, Cheng-Guo Duan, Zhong-Hui Zhang · 2007 · Journal of Virology · 77 citations

🆕 Influential since 2022

• The dicing activity of DCL3 and DCL4 is negatively affected by flavonoids

  Midori Tabara, Riho Yamanashi, Kazunori Kuriyama · 2022 · Plant Molecular Biology · 6 citations

• Inhibition of DCL4 activity by maternally supplied flavonoid aglycons induces a bicolor pattern in the saddle soybean seed coat

  Riho Yamanashi, Kazunori Kuriyama, Keita Sawai · 2025 · The Plant Journal · 3 citations

• Molecular basis of plant DCL4 action that outcompetes DCL2

  Yuelin Liu, Li Feng, Changshi Wang · 2026 · Nature Plants · 3 citations

• Molecular basis of DRB4-assisted long RNA processing and 21-nucleotide siRNA biogenesis by DCL4 in plants

  Changshi Wang, Cheng Chi, Yuelin Liu · 2026 · Nature Plants · 2 citations

• 2b proteins of highly virulent cucumber mosaic virus strains are associated with suppression of DCL4 activity

  Toshiyuki Fukuhara, Shuhei Miyashita, Nobuhiro Suzuki · 2026 · Plant and Cell Physiology · 1 citations

📚 Books worth reading

• Journal of the American Oriental SocietyAmerican Oriental Society · 1843
• The MonthSimpkin, Marshall, and Co. · 1864
• Corporat leverage - revisitedSandip Sinha · 2009
• The annual address of the Rt. Rev. I. Hellmuth, D.D., D.C.L., Bishop of Huron, delivered before the synod of the diocese, in "Bishop Cronyn Hall," London, Ont., June 4, 1873Church of England. Diocese of Huron. Bishop (1872-1883 : Hellmuth) · 1873
• Journal of a special meeting of the Synod of the Diocese of Toronto held for the election of a bishopChurch of England. Diocese of Toronto. · 1879
• 📕Domain Adaptation and Representation Transfer, and Distributed and Collaborative LearningShadi Albarqouni, Spyridon Bakas · 2020
• 📕The sermon delivered by the Rt. Rev. George Augustus Selwyn, D.D., D.C.L., Lord Bishop of Lichfield, before a general convention of the Protestant Episcopal Church in the United States of America, held in Baltimore, Maryland, October 4-26, A.D., 1871Selwyn, George Augustus · 1871
• 📕A letter to the Right Rev. the Lord Bishop of Winchester, relative to the case of the Rev. Richard Walker, D.C.L. amoved from his fellowship in St. Mary Magdalen College, Oxford, March the 9th; restored on appeal, May the 4th, 1769. By the Reverend Ambrose Kent, ..Ambrose Kent · 1769

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• Trans-acting siRNA Trans-acting siRNA (abbreviated "ta-siRNA" or "tasiRNA") are a class of small interfering RNA (siRNA) that repress gene expression through post-transcriptional…
• DCL2 DCL2 (an abbreviation of Dicer-like 2) is a gene in plants that codes for the DCL2 protein, a ribonuclease III enzyme involved in processing exogenous…
• DCL3 DCL3 (Dicer-like 3) is a plant gene that encodes a ribonuclease III enzyme involved in the RNA-directed DNA methylation (RdDM) pathway, a plant-specific…
• Phased small interfering RNA Phased small interfering RNAs (phasiRNAs) are a class of plant small RNAs produced from precursor PHAS transcripts in a precise, regularly spaced, or "phased"…
• DCL5 DICER-LIKE 5 (DCL5) is a plant Dicer-like endoribonuclease that functions in the biogenesis of 24-nucleotide reproductive phased small interfering RNAs…
• Dicer Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the…
• MiR390 microRNA precursor family The miR390 microRNA precursor family is a conserved plant microRNA family; mature miR390 is produced from MIR390 precursor transcripts. miR390 functions…
• RNA-induced silencing complex The RNA-induced silencing complex, or RISC, is a multiprotein complex, specifically a ribonucleoprotein, which functions in gene silencing via a variety…