Everything about CLPP

🧭 Start here: a 6-step reading path

1. Read the overview: CLPPA 5-minute orientation
2. Skim a recent paper: Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small moleculesInfluential work since 2022
3. Pick up a classic book: Subcellular localization and compartmentalization of the ClpP proteases in B. subtilisThe most-reprinted book on the subject
4. Read the landmark paper: Activated ClpP kills persisters and eradicates a chronic biofilm infectionCited 646 times
5. Go sideways: CLPA closely related topic
6. Go sideways: ATP-dependent Clp protease proteolytic subunitA closely related topic

🏆 Landmark papers (most cited)

• Activated ClpP kills persisters and eradicates a chronic biofilm infection

  B. P. Conlon, E. S. Nakayasu, L. E. Fleck · 2013 · Nature · 646 citations

• ClpP Mediates Activation of a Mitochondrial Unfolded Protein Response in C. elegans

  Cole M. Haynes, Kseniya Petrova, Cristina Benedetti · 2007 · Developmental Cell · 581 citations

• The Structure of ClpP at 2.3 Å Resolution Suggests a Model for ATP-Dependent Proteolysis

  Jimin Wang, James A Hartling, John M Flanagan · 1997 · Cell · 533 citations

• Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

  Jo Ishizawa, Sarah F. Zarabi, R. Eric Davis · 2019 · Cancer Cell · 357 citations

• Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

  Alicia Cole, Zezhou Wang, Etienne Coyaud · 2015 · Cancer Cell · 344 citations

• Assessing shifts in microbial community structure across a range of grasslands of differing management intensity using CLPP, PLFA and community DNA techniques

  S.J Grayston, C.D Campbell, R.D Bardgett · 2004 · Applied Soil Ecology · 329 citations

• Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence

  Dorte Frees, Saara N. A. Qazi, Philip J. Hill · 2003 · Molecular Microbiology · 312 citations

• Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram‐positive bacteria

  Dorte Frees, Kirsi Savijoki, Pekka Varmanen · 2007 · Molecular Microbiology · 269 citations

🆕 Influential since 2022

• Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules

  Mark F. Mabanglo, Walid A. Houry · 2022 · Journal of Biological Chemistry · 80 citations

• Cellular functions of the ClpP protease impacting bacterial virulence

  Mazen E. Aljghami, Marim M. Barghash, Emily Majaesic · 2022 · Frontiers in Molecular Biosciences · 64 citations

• Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma

  Pengyu Wang, Tao Zhang, Xinjing Wang · 2022 · Cell Chemical Biology · 61 citations

• ClpP inhibitors are produced by a widespread family of bacterial gene clusters

  Elizabeth J. Culp, David Sychantha, Christian Hobson · 2022 · Nature Microbiology · 59 citations

• Substrates and interactors of the ClpP protease in the mitochondria

  Mark F. Mabanglo, Vaibhav Bhandari, Walid A. Houry · 2022 · Current Opinion in Chemical Biology · 55 citations

📚 Books worth reading

• 📕Subcellular localization and compartmentalization of the ClpP proteases in B. subtilisJames Spencer Kain · 2008
• 📕Subcellular localization and compartmentalization of the ClpP proteases in Bacillus subtilisJames Spencer Kain · 2008
• 📕L'École primaire Tuzolana réhabilitée par l'autorité provinciale grâce au plaidoyer du comité local de gouvernance participative (CLGP/Basoko) appuyé par la cellule de liaison parlementaire provinciale (CLPP/Bandundu)Commission Episcopale Justice et Paix RDC (CEJP), Ville de Bandundu · 2014
• 📕Manual de organización de los consejos comunales y consejo local de planificación públicaHilda Herrera Brito · 2006
• 📕TEORIA Y PRACTICA DE LA CONTRALORIA SOCIALHilda Herrera Brita · 2009
• MANUAL DE ORGANIZACION DE LOS CONSEJOS COMUNALESHILDA HERRERA BRITO · 2008

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• CLP CLP may stand for: CLP protease family, a family of proteolytic enzymes Endopeptidase Clp, an enzyme complex ATP-dependent Clp protease proteolytic subunit…
• ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit (ClpP) is an enzyme that in humans is encoded by the CLPP gene. This protein is an essential component to…
• Clp protease family In molecular biology, the CLP protease family is a family of serine peptidases belong to the MEROPS peptidase family S14 (ClpP endopeptidase family, clan…
• ClpX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial is an enzyme that in humans is encoded by the CLPX gene. This protein is a member…
• Endopeptidase Clp Endopeptidase Clp (EC 3.4.21.92, endopeptidase Ti, caseinolytic protease, protease Ti, ATP-dependent Clp protease, ClpP, Clp protease). This enzyme catalyses…
• HslVU The heat shock proteins HslV and HslU (HslVU complex; also known as ClpQ and ClpY respectively, or ClpQY) are expressed in many bacteria such as E. coli…
• Calpain-6 Calpain-6 (also known as calpamodulin) is a protein in humans that is encoded by the CAPN6 gene. Calpains are a ubiquitous, well-conserved family of calcium-dep…
• Arginine kinase Arginine kinase (EC 2.7.3.3) is an enzyme that catalyzes the chemical reaction which converts L-arginine to N(omega)-phospho-L-arginine. The enzyme characterise…