Everything about ARPC4

🧭 Start here: a 6-step reading path

1. Read the overview: ARPC4A 5-minute orientation
2. Skim a recent paper: P798: Recurrent de novo variant in ARPC4 gene associated with neurodevelopmental disorder: A case reportInfluential work since 2022
3. Read the landmark paper: The role of ARPC4 in tip growth and alignment of the polar axis in filaments of Physcomitrella patensCited 67 times
4. Go sideways: ARPC5A closely related topic
5. Go sideways: ARPC3A closely related topic

🏆 Landmark papers (most cited)

• The role of ARPC4 in tip growth and alignment of the polar axis in filaments of Physcomitrella patens

  Pierre‐François Perroud, Ralph S. Quatrano · 2006 · Cell Motility · 67 citations

• ARPC4 promotes bladder cancer cell invasion and is associated with lymph node metastasis

  Ning Xu, Gen‐Yi Qu, Yu‐Peng Wu · 2019 · Journal of Cellular Biochemistry · 25 citations

• Expression of the ARPC4 Subunit of Human Arp2/3 Severely Affects Mycobacterium tuberculosis Growth and Suppresses Immunogenic Response in Murine Macrophages

  Anamika Ghosh, Sultan Tousif, Debapriya Bhattacharya · 2013 · PLoS ONE · 9 citations

• Akt-phosphorylated UFL1 UFMylates ArpC4 to promote metastasis

  Kailiang Zhao, Hao Hu, Debao Fang · 2025 · Nature Structural & Molecular Biology · 8 citations

• A recurrent, de novo pathogenic variant in ARPC4 disrupts actin filament formation and causes microcephaly and speech delay

  Dianne Laboy Cintron, Alison M. Muir, Abbey Scott · 2022 · Human Genetics and Genomics Advances · 8 citations

• Cytochalasin B Mitigates the Inflammatory Response in Lipopolysaccharide-Induced Mastitis by Suppressing Both the ARPC3/ARPC4-Dependent Cytoskeletal Changes and the Association Between HSP70 and the NLRP3 Inflammasome

  An Wang, Yan Chen, Bo Fang · 2025 · International Journal of Molecular Sciences · 7 citations

• UFMylation of ARPC4 facilitates lamellipodia formation and promotes cancer metastasis

  Miao Wang, Yu-Sheng Cong · 2025 · Nature Structural & Molecular Biology · 4 citations

• A novel variant of ARPC4‐related neurodevelopmental disorder

  Yukiko Kuroda, Tatsuro Kumaki, Yoko Saito · 2022 · American Journal of Medical Genetics Part A · 3 citations

🆕 Influential since 2022

• P798: Recurrent de novo variant in ARPC4 gene associated with neurodevelopmental disorder: A case report

  Joselito Sobreira, Paloma Velez, Taynara Amancio · 2025 · Genetics in Medicine Open · 0 citations

📚 Books worth reading

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🔗 Related topics

• ARPC5 Actin-related protein 2/3 complex subunit 5 is a protein that in humans is encoded by the ARPC5 gene. This gene encodes one of seven subunits of the human…
• ARPC3 Actin-related protein 2/3 complex subunit 3 is a protein that in humans is encoded by the ARPC3 gene. This gene encodes one of seven subunits of the Arp2/3…
• ARPC2 Actin-related protein 2/3 complex subunit 2 is a protein that in humans is encoded by the ARPC2 gene. This gene encodes one of seven subunits of the human…
• ARPC1B Actin-related protein 2/3 complex subunit 1B is a protein that in humans is encoded by the ARPC1B gene. This gene encodes one of seven subunits of the…
• ACTR3 Actin-related protein 3 is a protein that in humans is encoded by the ACTR3 gene. The specific function of this gene has not yet been determined; however…
• ARPC1A Actin-related protein 2/3 complex subunit 1A is a protein that in humans is encoded by the ARPC1A gene. This gene encodes one of seven subunits of the…
• ACTR2 Actin-related protein 2 is a protein that in humans is encoded by the ACTR2 gene. The specific function of ACTR2 has not yet been determined. However,…
• Arp2/3 complex Arp2/3 complex (Actin Related Protein 2/3 complex) is a seven-subunit protein complex that plays a major role in the regulation of the actin cytoskeleton…