Everything about APOBEC3C

🧭 Start here: a 6-step reading path

1. Read the overview: APOBEC3CA 5-minute orientation
2. Skim a recent paper: Cytidine deaminases APOBEC3C and APOBEC3D promote DNA replication stress resistance in pancreatic cancer cellsInfluential work since 2022
3. Pick up a classic book: Origin and evolution of virusesThe most-reprinted book on the subject
4. Read the landmark paper: APOBEC3B and APOBEC3C Are Potent Inhibitors of Simian Immunodeficiency Virus ReplicationCited 252 times
5. Go sideways: APOBEC3BA closely related topic
6. Go sideways: APOBEC3HA closely related topic

🏆 Landmark papers (most cited)

• APOBEC3B and APOBEC3C Are Potent Inhibitors of Simian Immunodeficiency Virus Replication

  Qin Yu, Darlene Chen, Renate König · 2004 · Journal of Biological Chemistry · 252 citations

• Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities

  M.-A. Langlois · 2005 · Nucleic Acids Research · 163 citations

• The APOBEC3C crystal structure and the interface for HIV-1 Vif binding

  Shingo Kitamura, Hirotaka Ode, Masaaki Nakashima · 2012 · Nature Structural & Molecular Biology · 152 citations

• Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients

  E Dong, D P Gavin, Y Chen · 2012 · Translational Psychiatry · 110 citations

• Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity

  Axel V. Horn, Sabine Klawitter, Ulrike Held · 2013 · Nucleic Acids Research · 84 citations

• Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H

  Josef Köck, Hubert E. Blum · 2008 · Journal of General Virology · 82 citations

• Hepatitis B virus DNA is subject to extensive editing by the human deaminase APOBEC3C

  Thomas F. Baumert, Christine Rösler, Michael H. Malim · 2007 · Hepatology · 79 citations

• Species-specific Inhibition of APOBEC3C by the Prototype Foamy Virus Protein Bet

  Mario Perković, Stanislaw Schmidt, Daniela Marino · 2009 · Journal of Biological Chemistry · 73 citations

🆕 Influential since 2022

• Cytidine deaminases APOBEC3C and APOBEC3D promote DNA replication stress resistance in pancreatic cancer cells

  Tajinder Ubhi, Olga Zaslaver, Andrew T. Quaile · 2024 · Nature Cancer · 30 citations

• Aberrant APOBEC3C expression induces characteristic genomic instability in pancreatic ductal adenocarcinoma

  Yunzhen Qian, Yitao Gong, Xuan Zou · 2022 · Oncogenesis · 20 citations

• The cytidine deaminase APOBEC3C has unique sequence and genome feature preferences

  Grant W Brown · 2024 · GENETICS · 7 citations

• The role of APOBEC3C in modulating the tumor microenvironment and stemness properties of glioma: evidence from pancancer analysis

  Shoudu Zhang, Yugang Guo, Yuanzheng Hu · 2023 · Frontiers in Immunology · 7 citations

• Engineered APOBEC3C Sequencing Enables Bisulfite-Free and Direct Detection of DNA Methylation at a Single-Base Resolution

  Min Wang, Neng-Bin Xie, Ke-Ke Chen · 2022 · Analytical Chemistry · 7 citations

📚 Books worth reading

• Origin and evolution of virusesEsteban Domingo · 2008
• Viral genomesZhi Feng · 2009

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• APOBEC3B Probable DNA dC->dU-editing enzyme APOBEC-3B is a protein that in humans is encoded by the APOBEC3B gene. This gene is a member of the cytidine deaminase…
• APOBEC3H DNA dC->dU-editing enzyme APOBEC-3H, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H or APOBEC-related protein 10, is…
• APOBEC3A Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A, also known as APOBEC3A, or A3A is a gene of the APOBEC3 family found in primates,…
• APOBEC3D Probable DNA dC->dU-editing enzyme APOBEC-3D is a protein that in humans is encoded by the APOBEC3D gene. This gene is a member of the cytidine deaminase…
• APOBEC3G APOBEC3G (apolipoprotein B mRNA editing enzyme, catalytic subunit 3G) is a human enzyme encoded by the APOBEC3G gene that belongs to the APOBEC superfamily…
• APOBEC3F DNA dC->dU-editing enzyme APOBEC-3F is a protein that in humans is encoded by the APOBEC3F gene. This gene is a member of the cytidine deaminase gene family…
• APOBEC APOBEC ("apolipoprotein B mRNA editing enzyme, catalytic polypeptide") is a family of evolutionarily conserved cytidine deaminases. A mechanism of generating…
• Viral infectivity factor Viral infectivity factor, or Vif, is an accessory protein found in HIV and other lentiviruses. Its role is to disrupt the antiviral activity of the human…