Everything about APOBEC3B

🧭 Start here: a 6-step reading path

1. Read the overview: APOBEC3BA 5-minute orientation
2. Skim a recent paper: The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistanceInfluential work since 2022
3. Read the landmark paper: APOBEC3B is an enzymatic source of mutation in breast cancerCited 823 times
4. Go sideways: APOBECA closely related topic
5. Go sideways: APOBEC3AA closely related topic

🏆 Landmark papers (most cited)

• APOBEC3B is an enzymatic source of mutation in breast cancer

  Michael B. Burns, Lela Lackey, Michael A. Carpenter · 2013 · Nature · 823 citations

• Evidence for APOBEC3B mutagenesis in multiple human cancers

  Michael B Burns, Nuri A Temiz, Reuben S Harris · 2013 · Nature Genetics · 748 citations

• An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

  Kin Chan, Steven A Roberts, Leszek J Klimczak · 2015 · Nature Genetics · 428 citations

• DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

  Benjamin JM Taylor, Serena Nik-Zainal, Yee Ling Wu · 2013 · eLife · 359 citations

• Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer

  Serena Nik-Zainal, David C Wedge, Ludmil B Alexandrov · 2014 · Nature Genetics · 282 citations

• Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

  Ke Shi, Michael A Carpenter, Surajit Banerjee · 2016 · Nature Structural & Molecular Biology · 271 citations

• APOBEC3B and APOBEC3C Are Potent Inhibitors of Simian Immunodeficiency Virus Replication

  Qin Yu, Darlene Chen, Renate König · 2004 · Journal of Biological Chemistry · 252 citations

• APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells

  H. P. Bogerd · 2006 · Nucleic Acids Research · 248 citations

🆕 Influential since 2022

• The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance

  Deborah R. Caswell, Philippe Gui, Manasi K. Mayekar · 2023 · Nature Genetics · 97 citations

• APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer

  Jennifer L. McCann, Agnese Cristini, Emily K. Law · 2023 · Nature Genetics · 84 citations

• Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases

  Cameron Durfee, Nuri Alpay Temiz, Rena Levin-Klein · 2023 · Cell Reports Medicine · 50 citations

• APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection

  Lavanya Manjunath, Sunwoo Oh, Pedro Ortega · 2023 · Nature Communications · 49 citations

• Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer

  Michael A. Carpenter, Nuri A. Temiz, Mahmoud A. Ibrahim · 2023 · PLOS Genetics · 47 citations

📚 Books worth reading

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🔗 Related topics

• APOBEC APOBEC ("apolipoprotein B mRNA editing enzyme, catalytic polypeptide") is a family of evolutionarily conserved cytidine deaminases. A mechanism of generating…
• APOBEC3A Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A, also known as APOBEC3A, or A3A is a gene of the APOBEC3 family found in primates,…
• APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C is a protein that in humans is encoded by the APOBEC3C gene. A3C belong to the A3 family of cytidine deaminases that…
• APOBEC1 Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 also known as C->U-editing enzyme APOBEC-1 is a protein that in humans is encoded by the…
• APOBEC3F DNA dC->dU-editing enzyme APOBEC-3F is a protein that in humans is encoded by the APOBEC3F gene. This gene is a member of the cytidine deaminase gene family…
• APOBEC3H DNA dC->dU-editing enzyme APOBEC-3H, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H or APOBEC-related protein 10, is…
• APOBEC3G APOBEC3G (apolipoprotein B mRNA editing enzyme, catalytic subunit 3G) is a human enzyme encoded by the APOBEC3G gene that belongs to the APOBEC superfamily…
• APOBEC2 Probable C->U-editing enzyme APOBEC-2 is a protein that in humans is encoded by the APOBEC2 gene. GRCh38: Ensembl release 89: ENSG00000124701 – Ensembl…