Everything about Target selection
Target selection is the process by which axons selectively target other cells for synapse formation. Synapses are structures which enable electrical or chemical signals to pass between nerves. While the mechanisms governing target specificity remain incompletely understood, it has been shown in many organisms that a combination of genetic and activity-based mechanisms govern initial target selection and refinement. The process of target selection has multiple steps that include axon pathfinding when neurons extend processes to specific regions, cellular target selection when neurons choose appropriate partners in a target region from a multitude of potential partners, and subcellular target selection where axons often target particular regions of a partner neuron. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Target selectionA 5-minute orientation
- Skim a recent paper: Target Selection and Validation of DESI Luminous Red GalaxiesInfluential work since 2022
- Pick up a classic book: Media planning workbookThe most-reprinted book on the subject
- Read the landmark paper: Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapiesCited 4,869 times
- Go sideways: SynaptogenesisA closely related topic
- Go sideways: Synaptic stabilizationA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
TARGET SITE SELECTION IN TRANSPOSITION
Saccade Target Selection During Visual Search
Target selection for CAR-T therapy
Target selection in drug discovery
Selection Response in Subdivided Target Regions
Target-Constrained Interference-Minimized Band Selection for Hyperspectral Target Detection
Burglar Target Selection
🆕 Influential since 2022
📚 Books worth reading
Media planning workbookWilliam B. Goodrich, Jack Z. Sissors · 1996
Escaping the Over-Targeting TrapMostafa Nawareg · 2025
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Synaptogenesis Synaptogenesis is the formation of synapses between neurons in the nervous system. Although it occurs throughout a healthy person's lifespan, an explosion…
- Synaptic stabilization Synaptic stabilization is crucial in the developing and adult nervous systems and is considered a result of the late phase of long-term potentiation (LTP)…
- Synaptotropic hypothesis The synaptotropic hypothesis, also called the synaptotrophic hypothesis, is a neurobiological hypothesis of neuronal growth and synapse formation. The…
- Role of cell adhesions in neural development Cellular adhesions can be defined as proteins or protein aggregates that form mechanical and chemical linkages between the intracellular and extracellular…
- Cellular neuroscience Cellular neuroscience is a branch of neuroscience concerned with the study of neurons at a cellular level. This includes morphology and physiological properties…
- Synapse In the nervous system, a synapse is a structure that allows a neuron to exchange (receive or send) signals with another cell in its immediate vicinity…
- Chemical synapse Chemical synapses are biological junctions through which neurons' signals can be sent to each other and to non-neuronal cells such as those in muscles…
- Axon terminal Axon terminals (also called terminal boutons, synaptic boutons, end-feet, or presynaptic terminals) are distal terminations of the branches of an axon…