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Everything about Structure validation

Process of evaluating 3-dimensional atomic models of biomacromolecules

Macromolecular structure validation is the process of evaluating reliability for 3-dimensional atomic models of large biological molecules such as proteins and nucleic acids. These models, which provide 3D coordinates for each atom in the molecule, come from structural biology experiments such as x-ray crystallography or nuclear magnetic resonance (NMR). The validation has three aspects: 1) checking on the validity of the thousands to millions of measurements in the experiment; 2) checking how consistent the atomic model is with those experimental data; and 3) checking consistency of the model with known physical and chemical properties. Wikipedia →

🧭 Start here: a 6-step reading path

  1. Read the overview: Structure validationA 5-minute orientation
  2. Skim a recent paper: Hybrid-self-centring damper for industrial structure: Development and experimental validationInfluential work since 2022
  3. Pick up a classic book: Welt und WirkungsprinzipThe most-reprinted book on the subject
  4. Read the landmark paper: Structure validation in chemical crystallographyCited 14,354 times
  5. Go sideways: Acta Crystallographica Section DA closely related topic
  6. Go sideways: Difference density mapA closely related topic

📖 Definitions

No dictionary entry for this exact phrase.

🗂️ The subject at a glance

  1. Historical summary
  2. Stages of validation
  3. Validation for crystallography
  4. In nuclear magnetic resonance
  5. In cryo-EM
  6. In SAXS
  7. For computational biology
  8. Link references

🏆 Landmark papers (most cited)

🆕 Influential since 2022

📚 Books worth reading

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics