Everything about Structural bioinformatics
Bioinformatics subfield
Structural bioinformatics is the branch of bioinformatics that is related to the analysis and prediction of the three-dimensional structure of biological macromolecules such as proteins, RNA, and DNA. It deals with generalizations about macromolecular 3D structures such as comparisons of overall folds and local motifs, principles of molecular folding, evolution, binding interactions, and structure/function relationships, working both from experimentally solved structures and from computational models. The term structural has the same meaning as in structural biology, and structural bioinformatics can be seen as a part of computational structural biology. The main objective of structural bioinformatics is the creation of new methods of analysing and manipulating biological macromolecular data in order to solve problems in biology and generate new knowledge. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Structural bioinformaticsA 5-minute orientation
- Skim a recent paper: Deep learning in structural bioinformatics: current applications and future perspectivesInfluential work since 2022
- Pick up a classic book: Molecular biology of the geneThe most-reprinted book on the subject
- Read the landmark paper: The Bio3D packages for structural bioinformaticsCited 519 times
- Go sideways: Internal Coordinate MechanicsA closely related topic
- Go sideways: Root mean square deviation of atomic positionsA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🏆 Landmark papers (most cited)
The Bio3D packages for structural bioinformatics
RPBS: a web resource for structural bioinformatics
Structural Bioinformatics of the Interactome
Biskit—A software platform for structural bioinformatics
Structural Bioinformatics Prediction of Membrane-binding Proteins
Protein structural bioinformatics: An overview
Ion channels: structural bioinformatics and modelling
Structural bioinformatics of the human spliceosomal proteome
🆕 Influential since 2022
Deep learning in structural bioinformatics: current applications and future perspectives
GenomeSyn: a bioinformatics tool for visualizing genome synteny and structural variations
Structural bioinformatics for rational drug design
Structural Bioinformatics Applied to Acetylcholinesterase Enzyme Inhibition
Identification of type VI secretion system effector-immunity pairs using structural bioinformatics
📚 Books worth reading
Molecular biology of the geneJames D. Watson, Nancy H. Hopkins · 1965- 📕Introduction to protein structure predictionHuzefa Rangwala · 2010
Structural bioinformaticsJenny Gu · 2009- 📕Structural BioinformaticsForbes J. Burkowski · 2008
Lecture Notes on Computational Structural BiologyZhijun Wu · 2008
Video BioinformaticsBir Bhanu, Prue Talbot · 2015
Algorithms on Trees and GraphsGabriel Valiente · 2002
From Protein Structure to Function with BioinformaticsDaniel J. Rigden · 2017
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Internal Coordinate Mechanics Internal Coordinate Mechanics (ICM) is a software program and algorithm to predict low-energy conformations of molecules by sampling the space of internal…
- Root mean square deviation of atomic positions In bioinformatics, the root mean square deviation of atomic positions, or simply root mean square deviation (RMSD), is the measure of the average distance…
- Structural alignment Structural alignment attempts to establish homology between two or more polymer structures based on their shape and three-dimensional conformation. This…
- Molecular Operating Environment Molecular Operating Environment (MOE) is a drug discovery software platform that integrates visualization, modeling and simulations, as well as methodology…
- Scoring functions for docking In the fields of computational chemistry and molecular modelling, scoring functions are mathematical functions used to approximately predict the binding…
- Protein Data Bank The Protein Data Bank (PDB) is a database for the three-dimensional structural data of large biological molecules such as proteins and nucleic acids, which…
- Protein structure prediction Protein structure prediction is the inference of the three-dimensional structure of a protein from its amino acid sequence—that is, the prediction of its…
- Biological data visualization Biological data visualization is a branch of bioinformatics concerned with the application of computer graphics, scientific visualization, and information…