Everything about Sequence
Finite or infinite ordered list of elements
In mathematics, a sequence is a collection of objects possibly with repetition, that come in a specified order. Like a set, it contains members. Unlike a set, the same elements can appear multiple times at different positions in a sequence, and unlike a set, the order does matter. The notion of a sequence can be generalized to an indexed family, defined as a function from an arbitrary index set. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: SequenceA 5-minute orientation
- Skim a recent paper: The complete sequence of a human genomeInfluential work since 2022
- Pick up a classic book: A Court of Thorns and RosesThe most-reprinted book on the subject
- Read the landmark paper: Trimmomatic: a flexible trimmer for Illumina sequence dataCited 64,878 times
- Go sideways: Limit (mathematics)A closely related topic
- Go sideways: Series (mathematics)A closely related topic
📖 Definitions
Noun A set of things next to each other in a set order; a series.
Noun The state of being sequent or following; order of succession.
Noun A series of musical phrases where a theme or melody is repeated, with some change each time, such as in pitch or length (example: opening of Beethoven's Fifth Symphony).
Noun A musical composition used in some Catholic Masses between the readings. The most famous sequence is the Dies Irae (Day of Wrath) formerly used in funeral services.
🏆 Landmark papers (most cited)
Trimmomatic: a flexible trimmer for Illumina sequence data
The Sequence Alignment/Map format and SAMtools
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability
MUSCLE: multiple sequence alignment with high accuracy and high throughput
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools
Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
🆕 Influential since 2022
The complete sequence of a human genome
Robust deep learning–based protein sequence design using ProteinMPNN
Search and sequence analysis tools services from EMBL-EBI in 2022
The EMBL-EBI Job Dispatcher sequence analysis tools framework in 2024
InterPro: the protein sequence classification resource in 2025
📚 Books worth reading
A Court of Thorns and RosesSarah J. Maas · 2013
When You Bit...Adam Fieled · 2006
Gene Cloning and DNA AnalysisT. A. Brown · 2001
Biological sequence analysisRichard M. Durbin, Sean R. Eddy · 1998
BioinformaticsAndreas D. Baxevanis, B. F. Francis Ouellette · 2001
Introduction to cancer biologyRobin Hesketh · 2012
Automatic sequencesJean-Paul Allouche, Jeffrey Shallit · 2003
BioinformaticsDavid W. Mount · 2001
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
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- Limit of a sequence In mathematics, the limit of a sequence is the value that the terms of a sequence "tend to", and is often denoted using the lim symbol (e.g., limn→∞an)…