Everything about Sepsis

🧭 Start here: a 6-step reading path

1. Read the overview: SepsisA 5-minute orientation
2. Skim a recent paper: Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroupInfluential work since 2022
3. Pick up a classic book: Sepsis and organ dysfunctionThe most-reprinted book on the subject
4. Read the landmark paper: The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)Cited 25,176 times
5. Go sideways: Septic shockA closely related topic
6. Go sideways: Multiple organ dysfunction syndromeA closely related topic

🏆 Landmark papers (most cited)

• The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

  Mervyn Singer, Clifford S. Deutschman, Christopher Warren Seymour · 2016 · JAMA · 25,176 citations

• The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure

  J. -L. Vincent, R. Moreno, J. Takala · 1996 · Intensive Care Medicine · 9,847 citations

• Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock

  Emanuel Rivers, Bryant Nguyen, Suzanne Havstad · 2001 · New England Journal of Medicine · 8,008 citations

• Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

  Kristina E Rudd, Sarah Charlotte Johnson, Kareha M Agesa · 2020 · The Lancet · 7,615 citations

• Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

  Roger C. Bone, Robert A. Balk, Frank B. Cerra · 1992 · Chest · 7,417 citations

• Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

  Derek C. Angus, Walter T. Linde-Zwirble, Jeffrey Lidicker · 2001 · Critical Care Medicine · 6,603 citations

• Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

  Andrew Rhodes, Laura E. Evans, Waleed Alhazzani · 2017 · Intensive Care Medicine · 5,115 citations

• The Epidemiology of Sepsis in the United States from 1979 through 2000

  Greg S. Martin, David M. Mannino, Stephanie Eaton · 2003 · New England Journal of Medicine · 4,796 citations

🆕 Influential since 2022

• Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup

  Alexander Zarbock, Mitra K. Nadim, Peter Pickkers · 2023 · Nature Reviews Nephrology · 805 citations

• International Consensus Criteria for Pediatric Sepsis and Septic Shock

  Luregn J. Schlapbach, R. Scott Watson, Lauren R. Sorce · 2024 · JAMA · 617 citations

• Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review

  Tatiana Barichello, Jaqueline S. Generoso, Mervyn Singer · 2022 · Critical Care · 455 citations

• Sepsis and Septic Shock

  Nuala J. Meyer, Hallie C. Prescott · 2024 · New England Journal of Medicine · 432 citations

• Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension

  The National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network · 2023 · New England Journal of Medicine · 425 citations

📚 Books worth reading

• Sepsis and organ dysfunctionArthur Baue, G. Berlot · 1997
• SepsisK. Reinhart, K. Eyrich · 1994
• ABC of sepsisTim Nutbeam · 2009
• Ueber die Wirkung faulender organischer Substanzen auf den lebenden thierischen OrganismusFranz Schweninger · 1866
• Dental infection controlRobert R. Runnells · 1985
• The sepsis textJ. L. Vincent · 2002
• The Tragedy of Childbed FeverIrvine Loudon · 2000
• 📕Pathologie buccale, péri-buccale et d'origine buccaleLouis Rousseau-Decelle · 1939

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• Septic shock Septic shock is a potentially fatal medical condition that occurs when sepsis, which is defined as an abnormal immune response to infection that leads…
• Multiple organ dysfunction syndrome Multiple organ dysfunction syndrome (MODS) is altered organ function in an acutely ill patient requiring immediate medical intervention. There are different…
• SOFA score The sequential organ failure assessment score (SOFA score), previously known as the sepsis-related organ failure assessment score, is used to track a person's…
• Septic abortion Septic abortion is any type of abortion (intentional termination or miscarriage), due to an upper genital tract bacterial infection including the inflammation…
• Systemic inflammatory response syndrome In immunology, systemic inflammatory response syndrome (SIRS) is an inflammatory state affecting the whole body. It is the body's response to an infectious…
• Surviving Sepsis Campaign The Surviving Sepsis Campaign (SSC) is a global initiative to bring together professional organizations in reducing mortality from sepsis. The purpose…
• Shock (circulatory) Shock is the state of insufficient blood flow to the tissues of the body as a result of problems with the circulatory system. Initial symptoms of shock…
• Bloodstream infection Bloodstream infections (BSIs) are infections of blood caused by blood-borne pathogens. The detection of microbes in the blood (most commonly accomplished…