Everything about SGI

🧭 Start here: a 6-step reading path

1. Read the overview: SGIA 5-minute orientation
2. Skim a recent paper: Phase 1, dose-escalation study of guadecitabine (SGI-110) in combination with pembrolizumab in patients with solid tumorsInfluential work since 2022
3. Pick up a classic book: Report from the desertThe most-reprinted book on the subject
4. Read the landmark paper: Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 studyCited 268 times
5. Go sideways: Silicon Graphics InternationalA closely related topic
6. Go sideways: Silicon GraphicsA closely related topic

🏆 Landmark papers (most cited)

• Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study

  Jean-Pierre J Issa, Gail Roboz, David Rizzieri · 2015 · The Lancet Oncology · 268 citations

• Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

  Lisa S. Chen, Sanjeev Redkar, David Bearss · 2009 · Blood · 191 citations

• Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia

  Lisa S. Chen, Sanjeev Redkar, Pietro Taverna · 2011 · Blood · 160 citations

• Guadecitabine (SGI-110) in treatment-naive patients with acute myeloid leukaemia: phase 2 results from a multicentre, randomised, phase 1/2 trial

  Hagop M Kantarjian, Gail J Roboz, Patricia L Kropf · 2017 · The Lancet Oncology · 150 citations

• The SGI Origin

  James Laudon, Daniel Lenoski · 1997 · ACM SIGARCH Computer Architecture News · 97 citations

• Guadecitabine (SGI-110) in patients with intermediate or high-risk myelodysplastic syndromes: phase 2 results from a multicentre, open-label, randomised, phase 1/2 trial

  Guillermo Garcia-Manero, Gail Roboz, Katherine Walsh · 2019 · The Lancet Haematology · 91 citations

• The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms

  Karthika Natarajan, Jasjeet Bhullar, Suneet Shukla · 2013 · Biochemical Pharmacology · 88 citations

• The Novel, Small-Molecule DNA Methylation Inhibitor SGI-110 as an Ovarian Cancer Chemosensitizer

  Fang Fang, Joanne Munck, Jessica Tang · 2014 · Clinical Cancer Research · 85 citations

🆕 Influential since 2022

• Phase 1, dose-escalation study of guadecitabine (SGI-110) in combination with pembrolizumab in patients with solid tumors

  Dionysis Papadatos-Pastos, Wei Yuan, Abhijit Pal · 2022 · Journal for ImmunoTherapy of Cancer · 58 citations

• Measuring Policy Performance, Democracy, and Governance Capacities: A conceptual and methodological assessment of the Sustainable Governance Indicators (SGI)

  Aurel Croissant, Lars Pelke · 2022 · European Policy Analysis · 42 citations

• Integrated clinical and genomic evaluation of guadecitabine (SGI-110) in peripheral T-cell lymphoma

  Jonathan Wong, Emily Gruber, Belinda Maher · 2022 · Leukemia · 28 citations

• Analyzing national policy styles empirically using the Sustainable Governance Indicators (SGI): insights into long‐term patterns of policy‐making

  Jale Tosun, Michael Howlett · 2022 · European Policy Analysis · 27 citations

• Identifying diverse paths toward successful policy performance in Organization for Economic Co‐operation and Development (OECD) and European Union countries: A Qualitative Comparative Analysis (QCA) exploitation of the Sustainable Governance Indicators (SGI) data

  Giulia Bazzan, Priscilla Álamos‐Concha, Benoît Rihoux · 2022 · European Policy Analysis · 26 citations

📚 Books worth reading

• Report from the desertAnonymous · 2008

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• Silicon Graphics International Silicon Graphics International Corp. (SGI; formerly Rackable Systems, Inc.) was an American manufacturer of computer hardware and software, including high-perfo…
• Silicon Graphics Silicon Graphics, Inc. (stylized as SiliconGraphics before 1999, later rebranded SGI, historically known as Silicon Graphics Computer Systems or SGCS)…
• IRIX IRIX (/ˈaɪrɪks/, EYE-ricks, a portmanteau of IRIS and UNIX) is a discontinued operating system developed by Silicon Graphics (SGI) to run on the company's…
• Kurt Akeley Kurt Akeley (born June 8, 1958) is an American computer graphics engineer. Akeley was elected into the National Academy of Engineering in 2005 for contributions…
• Edward R. McCracken Edward Ray McCracken (born December 1943) is an American businessman who was CEO of Silicon Graphics (SGI) from 1984 to 1997. Under his leadership, SGI…
• Charles Kuta Charles Stanley "Herb" Kuta (born 1956) is an American electronics engineer and software engineer who was a co-founder of Silicon Graphics, a major graphics…
• Richard Belluzzo Richard "Rick" Belluzzo (born November 26, 1953) is an American businessman who worked as an executive at Hewlett-Packard (HP), Silicon Graphics (SGI)…
• SGI Altix Altix is a line of server computers and supercomputers produced by Silicon Graphics (and successor company Silicon Graphics International), based on Intel…