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Everything about Pyrophosphate

Class of chemical compounds

In chemistry, pyrophosphates are phosphorus oxyanions that contain two phosphorus atoms in a P−O−P linkage. A number of pyrophosphate salts exist, such as disodium pyrophosphate and tetrasodium pyrophosphate, among others. Often pyrophosphates are called diphosphates. The parent pyrophosphates are derived from partial or complete neutralization of pyrophosphoric acid. The pyrophosphate bond is also sometimes referred to as a phosphoanhydride bond, a naming convention which emphasizes the loss of water that occurs when two phosphates form a new P−O−P bond, and which mirrors the nomenclature for anhydrides of carboxylic acids. Pyrophosphates are found in ATP and other nucleotide triphosphates, which are important in biochemistry. The term pyrophosphate is also the name of esters formed by the condensation of a phosphorylated biological compound with inorganic phosphate, as for dimethylallyl pyrophosphate. This bond is also referred to as a high-energy phosphate bond. Wikipedia →

🧭 Start here: a 6-step reading path

  1. Read the overview: PyrophosphateA 5-minute orientation
  2. Skim a recent paper: Calcium pyrophosphate deposition diseaseInfluential work since 2022
  3. Pick up a classic book: ThiamineThe most-reprinted book on the subject
  4. Read the landmark paper: Detection of Loop-Mediated Isothermal Amplification Reaction by Turbidity Derived from Magnesium Pyrophosphate FormationCited 1,506 times
  5. Go sideways: Phosphoric acids and phosphatesA closely related topic
  6. Go sideways: ATP diphosphataseA closely related topic

📖 Definitions

Noun Any salt or ester of pyrophosphoric acid.

🗂️ The subject at a glance

  1. Acidity
  2. Preparation
  3. Biochemistry
  4. Physiological role
  5. As a food additive

🏆 Landmark papers (most cited)

🆕 Influential since 2022

📚 Books worth reading

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

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