Everything about Profile-guided optimization

🧭 Start here: a 6-step reading path

1. Read the overview: Profile-guided optimizationA 5-minute orientation
2. Skim a recent paper: Profile-guided optimisation for indirect branches in a binary translatorInfluential work since 2022
3. Pick up a classic book: 60 Days to LinkedIn MasteryThe most-reprinted book on the subject
4. Read the landmark paper: Mode selective generation of guided waves by systematic optimization of the interfacial shear stress profileCited 13 times
5. Go sideways: Binary optimizerA closely related topic
6. Go sideways: Just-in-time compilationA closely related topic

🏆 Landmark papers (most cited)

• Mode selective generation of guided waves by systematic optimization of the interfacial shear stress profile

  Peyman Yazdanpanah Moghadam, Nicolas Quaegebeur, Patrice Masson · 2014 · Smart Materials and Structures · 13 citations

• Structure-guided optimization of a novel class of ASK1 inhibitors with increased sp3 character and an exquisite selectivity profile

  Simone V. Bigi-Botterill, Anthony Ivetac, Erica L. Bradshaw · 2020 · Bioorganic & Medicinal Chemistry Letters · 9 citations

• Profile-guided proactive garbage collection for locality optimization

  Wen-ke Chen, Sanjay Bhansali, Trishul Chilimbi · 2006 · ACM SIGPLAN Notices · 7 citations

• Profile-guided optimization across process boundaries

  Erik Johansson, Sven-Olof Nyström · 2000 · ACM SIGPLAN Notices · 4 citations

• Method for Profile-Guided Optimization of Android Applications Using Random Forest

  Andrei Visochan, Andrey Stroganov, Ivan Titarenko · 2022 · IEEE Access · 4 citations

• Cooperative Profile Guided Optimizations

  Mark Stephenson, Ram Rangan, Stephen W. Keckler · 2021 · Computer Graphics Forum · 2 citations

• Diagnostic-Guided Dynamic Profile Optimization for LLM-based User Simulators in Sequential Recommendation

  Hongyang Liu, Zhu Sun, Tianjun Wei · 2026 · Proceedings of the AAAI Conference on Artificial Intelligence · 2 citations

• Thermal-kinetics-guided sintering-profile optimization and interpretable fracture-mechanism learning for pressureless sintered Ag pastes

  Zezhan Li, Wei Du, Xuyang Yan · 2026 · Applied Materials Today · 1 citations

🆕 Influential since 2022

• Profile-guided optimisation for indirect branches in a binary translator

  Jyun-Siang Huang, Wuu Yang, Yi-Ping You · 2022 · Connection Science · 4 citations

• Influence of μm-level profile slopes on vacuum DC flashover: a model guided design optimization

  Yuhang Huang, Sile Chen, Chao Wang · 2026 · IEEE Transactions on Dielectrics and Electrical Insulation · 0 citations

• Artificial intelligence-guided optimization of Suillus lakei extracts enhancing bioactive profile and functional properties for future food applications

  Mustafa Sevindik, Iskender Karaltı, Tetiana Krupodorova · 2026 · Scientific Reports · 0 citations

• Prognostic impact of echocardiographic optimal profile and echo-guided LVAD speed optimization at six months after LVAD implantation

  V A R Thirupathirajan, J Guzman Bofarull, G Gallone · 2026 · European Journal of Heart Failure · 0 citations

• Machine learning-guided optimization of probiotic chickpea milk fermentation enhances antioxidant capacity, volatile aroma profile, and sensory quality

  Ping Tang, Siew-Young Quek, Yi-Chen Lo · 2026 · Future Foods · 0 citations

📚 Books worth reading

• 60 Days to LinkedIn MasteryJosh Steimle, Virginie Cantin · 2021
• PTAexamScott M. Giles · 2010
• 📕Engineering Decision Making and Risk ManagementJeffrey W. Herrmann · 2015
• Professional iPhone and iPad Application DevelopmentGene Backlin · 2010
• Computational drug discovery and designRiccardo Baron · 2012
• CANCER. Targeting Killer CellsGilbert Mertens · 2009
• 📕Facebook Profile Growth and Optimization GuideQuintin Ford · 2019
• 📕Linkedin Profile Optimization Guide : Learn How to Optimize Your Linkedin Profile for Good VisibilityTorrie Ganska · 2021

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

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• Profiling (computer programming) In software engineering, profiling (program profiling, software profiling) is a form of dynamic program analysis that measures, for example, the space…
• Ahead-of-time compilation In computer science, ahead-of-time compilation (AOT compilation) is the act of compiling an (often) higher-level programming language into an (often) lower-leve…
• Java Development Kit The Java Development Kit (JDK) is a software development kit for development of a Java platform application. The JDK is designed to be mainly used to communicat…
• Intel Fortran Compiler Intel Fortran Compiler, as part of Intel OneAPI HPC toolkit, is a group of Fortran compilers from Intel for Windows, macOS, and Linux. The compilers generate…
• Dynamic program analysis Dynamic program analysis is the act of analyzing software that involves executing a program – as opposed to static program analysis, which does not execute…
• Tracing just-in-time compilation Tracing just-in-time compilation is a technique used by virtual machines to optimize the execution of a program at runtime. This is done by recording a…