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Everything about Procyclin
Surface coating protein of trypanosome
Procyclins also known as procyclic acidic repetitive proteins or PARP are proteins developed in the surface coating of Trypanosoma brucei parasites while in their tsetse fly vector. The cell surface of the bloodstream form features a dense coat of variable surface glycoproteins (VSGs) which is replaced by an equally dense coat of procyclins when the parasite differentiates into the procylic form in the tsetse fly midgut. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: ProcyclinA 5-minute orientation
- Skim a recent paper: The bromodomain protein Bdf3 is sufficient to activate expression of a procyclin gene in bloodstream stage African trypanosomesInfluential work since 2022
- Read the landmark paper: Procyclin gene expression and loss of the variant surface glycoprotein during differentiation of Trypanosoma brucei.Cited 246 times
- Go sideways: Variant surface glycoproteinA closely related topic
- Go sideways: Trypanosoma bruceiA closely related topic
📖 Definitions
Noun A protein developed in the surface coating of trypanosomes whilst in the fly vector.
🗂️ The subject at a glance
No outline available.
🏆 Landmark papers (most cited)
Procyclin gene expression and loss of the variant surface glycoprotein during differentiation of Trypanosoma brucei.
RNA Polymerase I Transcribes Procyclin Genes and Variant Surface Glycoprotein Gene Expression Sites in Trypanosoma brucei
The surface coat of procyclic Trypanosoma brucei: Programmed expression and proteolytic cleavage of procyclin in the tsetse fly
Elements in the 3′ Untranslated Region of Procyclin mRNA Regulate Expression in Insect Forms of Trypanosoma brucei by Modulating RNA Stability and Translation
Procyclin: an unusual immunodominant glycoprotein surface antigen from the procyclic stage of African trypanosomes
Survival of Trypanosoma brucei in the Tsetse Fly Is Enhanced by the Expression of Specific Forms of Procyclin
Trypanosoma brucei: constitutive activity of the VSG and procyclin gene promoters.
A conserved stem-loop structure in the 3' untranslated region of procyclin mRNAs regulates expression in Trypanosoma brucei.
🆕 Influential since 2022
📚 Books worth reading
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🔗 Related topics
- Variant surface glycoprotein Variant surface glycoprotein (VSG) is a ~60kDa protein which densely packs the cell surface of protozoan parasites belonging to the genus Trypanosoma.…
- Trypanosoma brucei Trypanosoma brucei is a species of parasitic kinetoplastid belonging to the genus Trypanosoma that is present in sub-Saharan Africa. Unlike other protozoan…
- Coat protein Coat protein may refer to: Viral coat protein, a component of the capsid Variable surface glycoproteins or procyclins, surface coat proteins of either…
- Trypanosomatida Trypanosomatida is a group of kinetoplastid unicellular organisms distinguished by having only a single flagellum. The name is derived from the Greek trypano…
- Wendy Gibson Wendy Gibson is Professor of Protozoology at University of Bristol, specialising in trypanosomes and molecular parasitology. Wendy C. Gibson studied B…
- Keith Matthews (biologist) Keith Roland Matthews (born 24 June 1964) is a British cell biologist and parasitologist, currently a professor of parasite biology in the School of Biological…
- African trypanosomiasis African trypanosomiasis is an insect-borne parasitic infection of humans and other animals caused by the protozoan species Trypanosoma brucei, which is…
- Antigenic variation Antigenic variation or antigenic alteration refers to the mechanism by which an infectious agent such as a protozoan, bacterium or virus alters the proteins…