Everything about Prefoldin
Protein family
Prefoldin (GimC) is a superfamily of proteins used in protein folding complexes. It is classified as a heterohexameric molecular chaperone in both archaea and eukarya, including humans. A prefoldin molecule works as a transfer protein in conjunction with a molecule of chaperonin to form a chaperone complex and correctly fold other nascent proteins. One of prefoldin's main uses in eukarya is the formation of molecules of actin for use in the eukaryotic cytoskeleton. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: PrefoldinA 5-minute orientation
- Skim a recent paper: Prefoldin Function in Cellular Protein Homeostasis and Human DiseasesInfluential work since 2022
- Pick up a classic book: Protein folding in the cellThe most-reprinted book on the subject
- Read the landmark paper: Prefoldin, a Chaperone that Delivers Unfolded Proteins to Cytosolic ChaperoninCited 518 times
- Go sideways: PFDN4A closely related topic
- Go sideways: PFDN1A closely related topic
📖 Definitions
Noun Any of a family of proteins used in protein-folding complexes. A prefoldin molecule works as a transfer protein in conjunction with a molecule of chaperonin to form a chaperone complex and correctly fold other nascent proteins.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Prefoldin, a Chaperone that Delivers Unfolded Proteins to Cytosolic Chaperonin
HSP90 and Its R2TP/Prefoldin-like Cochaperone Are Involved in the Cytoplasmic Assembly of RNA Polymerase II
Structure of the Molecular Chaperone Prefoldin
Crystal Structure of Skp, a Prefoldin-like Chaperone that Protects Soluble and Membrane Proteins from Aggregation
Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT
Prefoldin–Nascent Chain Complexes in the Folding of Cytoskeletal Proteins
Control of Nutrient-Sensitive Transcription Programs by the Unconventional Prefoldin URI
The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis
🆕 Influential since 2022
Prefoldin Function in Cellular Protein Homeostasis and Human Diseases
Prefoldin 2 contributes to mitochondrial morphology and function
Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin
Model of the external force field for the protein folding process—the role of prefoldin
Horseradish Peroxidase Catalyzed Silk–Prefoldin Composite Hydrogel Networks
📚 Books worth reading
- 📕Protein folding in the cellArthur Horwich · 2002
PrefoldinsNabil Djouder · 2018- 📕ArchaeaSakura Y. Kato · 2010
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- PFDN4 Prefoldin subunit 4 is a protein that in humans is encoded by the PFDN4 gene. This gene encodes a member of the prefoldin beta subunit family. The encoded…
- PFDN1 Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene. This gene encodes a member of the prefoldin beta subunit family. The encoded…
- PFDN5 Prefoldin subunit 5 is a protein that in humans is encoded by the PFDN5 gene. This gene encodes a member of the prefoldin alpha subunit family. The encoded…
- Chaperonin Chaperonins, abbreviated Cpn, Cpn60, or HSP60, are a family of heat shock proteins that assist in the folding of newly synthesized proteins and refolding…
- PFDN2 Prefoldin subunit 2 is a protein that in humans is encoded by the PFDN2 gene. This gene encodes a member of the prefoldin beta subunit family. The encoded…
- T-complex protein 1 subunit epsilon T-complex protein 1 subunit epsilon is a protein that in humans is encoded by the CCT5 gene. This gene encodes a molecular chaperone that is member of…
- CCT2 (gene) T-complex protein 1 subunit beta is a protein that in humans is encoded by the CCT2 gene. This gene encodes a molecular chaperone that is member of the…
- Tubulin Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily…