Everything about Phex

🧭 Start here: a 6-step reading path

1. Read the overview: PhexA 5-minute orientation
2. Skim a recent paper: Calcium‑dependent activation of PHEX, MEPE and DMP1 in osteocytesInfluential work since 2022
3. Pick up a classic book: PoliteiaThe most-reprinted book on the subject
4. Read the landmark paper: Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient miceCited 466 times
5. Go sideways: Anonymous P2PA closely related topic
6. Go sideways: Privacy in file sharing networksA closely related topic

🏆 Landmark papers (most cited)

• Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice

  Despina Sitara, Mohammed S. Razzaque, Martina Hesse · 2004 · Matrix Biology · 466 citations

• Regulation of Fibroblastic Growth Factor 23 Expression but Not Degradation by PHEX

  Shiguang Liu, Rong Guo, Leigh G. Simpson · 2003 · Journal of Biological Chemistry · 441 citations

• FGF-23 Inhibits Renal Tubular Phosphate Transport and Is a PHEX Substrate

  Ann E. Bowe, Richard Finnegan, Suzanne M. Jan de Beur · 2001 · Biochemical and Biophysical Research Communications · 285 citations

• FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization

  L. Darryl Quarles · 2003 · American Journal of Physiology-Endocrinology and Metabolism · 278 citations

• Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling

  Aline Martin, Shiguang Liu, Valentin David · 2011 · The FASEB Journal · 241 citations

• FGF23 is processed by proprotein convertases but not by PHEX

  Anna Benet-Pagès, Bettina Lorenz-Depiereux, Hans Zischka · 2004 · Bone · 226 citations

• MEPE-ASARM Peptides Control Extracellular Matrix Mineralization by Binding to Hydroxyapatite: An Inhibition Regulated by PHEX Cleavage of ASARM

  William N Addison, Yukiko Nakano, Thomas Loisel · 2008 · Journal of Bone and Mineral Research · 199 citations

• Phosphorylation-dependent inhibition of mineralization by osteopontin ASARM peptides is regulated by PHEX cleavage

  William N Addison, David L Masica, Jeffrey J Gray · 2010 · Journal of Bone and Mineral Research · 172 citations

🆕 Influential since 2022

• Calcium‑dependent activation of PHEX, MEPE and DMP1 in osteocytes

  Baris Donmez, Ege Karagur, Aysegul Donmez · 2022 · Molecular Medicine Reports · 14 citations

• X-linked hypophosphatemia caused by a deep intronic variant in PHEX identified by PCR-based RNA analysis of urine-derived cells

  Chelsey Grimbly, Karissa Ludwig, Zenghui Wu · 2023 · Bone · 11 citations

• Acquired Osteomalacia Associated with Autoantibodies against PHEX

  Yoshitomo Hoshino, Kazuo Okamoto, Tomohiro Ogawa · 2025 · New England Journal of Medicine · 11 citations

• X‐Linked Hypophosphatemia Caused by the Prevailing North American PHEX Variant c.*231A>G ; Exon 13–15 Duplication Is Often Misdiagnosed as Ankylosing Spondylitis and Manifests in Both Men and Women

  Kathryn McCrystal Dahir, Margo Black, Gary S Gottesman · 2022 · JBMR Plus · 11 citations

• A matter of origin - identification of SEMA3A, BGLAP, SPP1 and PHEX as distinctive molecular features between bone site-specific human osteoblasts on transcription level

  Weiping Zhang, Sibylle Rau, Konstantinos Kotzagiorgis · 2022 · Frontiers in Bioengineering and Biotechnology · 9 citations

📚 Books worth reading

• 📕PoliteiaArēs Diktaios · 1958
• 📕Arthra gia tēn Kavaphikē poiēsēHelenē Ladia · 1975
• 📕Gyrō apo tē synchronē Hellēnikē poiēsēAntreas Karantōnēs · 1961
• 📕Mia paradosē, mia peripeteiaDora Stratou · 1964
• 📕Ho Don KichōtēsMiguel de Cervantes Saavedra · 1944
• 📕Stē chasē kai stē phexēArkadios Pēgaios · 1971
• 📕Regulation of PHEX gene-expression and relation to phosphate homeostasisEvangelos Zoidis · 2000
• 📕K.P. Kavaphē hapanta ta peza / K.P. Kavaphē ; me epimeleia Giōrgou Ph. Phexē, parousiasē scholia Giōrgou PapoutsakēKōnstantinos Petrou Kabaphēs · 1963

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

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