Everything about Padlock

🧭 Start here: a 6-step reading path

1. Read the overview: PadlockA 5-minute orientation
2. Skim a recent paper: A Universal Strategy for Enhancing the Circulating miRNAs’ Detection Performance of Rolling Circle Amplification by Using a Dual-Terminal Stem-Loop PadlockInfluential work since 2022
3. Pick up a classic book: The padlock collectorThe most-reprinted book on the subject
4. Read the landmark paper: Padlock Probes: Circularizing Oligonucleotides for Localized DNA DetectionCited 650 times
5. Go sideways: Lock and keyA closely related topic
6. Go sideways: Mortise lockA closely related topic

🏆 Landmark papers (most cited)

• Padlock Probes: Circularizing Oligonucleotides for Localized DNA Detection

  Mats Nilsson, Helena Malmgren, Martina Samiotaki · 1994 · Science · 650 citations

• Signal amplification of padlock probes by rolling circle replication

  J. Baner, M. Nilsson, M. Mendel-Hartvig · 1998 · Nucleic Acids Research · 438 citations

• In situ genotyping individual DNA molecules by target-primed rolling-circle amplification of padlock probes

  Chatarina Larsson, Jørn Koch, Anders Nygren · 2004 · Nature Methods · 302 citations

• High Specific and Ultrasensitive Isothermal Detection of MicroRNA by Padlock Probe-Based Exponential Rolling Circle Amplification

  Haiyun Liu, Lu Li, Lili Duan · 2013 · Analytical Chemistry · 238 citations

• A microRNA detection system based on padlock probes and rolling circle amplification

  Søren Peter Jonstrup, Jørn Koch, Jørgen Kjems · 2006 · RNA · 222 citations

• Efficient in situ barcode sequencing using padlock probe-based BaristaSeq

  Xiaoyin Chen, Yu-Chi Sun, George M Church · 2017 · Nucleic Acids Research · 207 citations

• Padlock probes reveal single-nucleotide differences, parent of origin and in situ distribution of centromeric sequences in human chromosomes 13 and 21

  Mats Nilsson, Katerina Krejci, Jørn Koch · 1997 · Nature Genetics · 132 citations

• “Off” to “On” Surface-Enhanced Raman Spectroscopy Platform with Padlock Probe-Based Exponential Rolling Circle Amplification for Ultrasensitive Detection of MicroRNA 155

  Yi He, Xia Yang, Ruo Yuan · 2017 · Analytical Chemistry · 129 citations

🆕 Influential since 2022

• A Universal Strategy for Enhancing the Circulating miRNAs’ Detection Performance of Rolling Circle Amplification by Using a Dual-Terminal Stem-Loop Padlock

  Hanqing Xu, Xianlan Wu, Qian Liu · 2023 · ACS Nano · 44 citations

• A novel specific and ultrasensitive method detecting extracellular vesicles secreted from lung cancer by padlock probe-based exponential rolling circle amplification

  Lei He, Xiaocheng Yu, Rongrong Huang · 2022 · Nano Today · 38 citations

• PAIT effect: Padlock activator inhibits the trans-cleavage activity of CRISPR/Cas12a

  Xueying Lei, Lihua Ding, Xiaonan Yang · 2024 · Biosensors and Bioelectronics · 21 citations

• Exploring Mitochondrial Localization of SARS-CoV-2 RNA by Padlock Assay: A Pilot Study in Human Placenta

  Francesca Gabanella, Christian Barbato, Nicoletta Corbi · 2022 · International Journal of Molecular Sciences · 18 citations

• Padlock Probe–Based Targeted In Situ Sequencing: Overview of Methods and Applications

  Anastasia Magoulopoulou, Sergio Marco Salas, Katarína Tiklová · 2023 · Annual Review of Genomics and Human Genetics · 16 citations

📚 Books worth reading

• 📕The padlock collectorFranklin M. Arnall · 1972
• Opening combination padlocksBlack, Carl. · 2002
• Improvised Lock PickingSteven Hampton · 2003
• 📕Specifications for padlocks · 1900
• 📕Amended specifications for padlocks · 1896
• 📕Antique padlocksJack Roberts · 1990
• More Working Wooden LocksTim Detweiler · 2003
• 📕What's behind the Padlock Law?Evariste Dubé · 1938

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

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