Everything about PRKAA2

🧭 Start here: a 6-step reading path

1. Read the overview: PRKAA2A 5-minute orientation
2. Skim a recent paper: PRKAA2-mediated mitophagy regulates oxygen consumption in yak renal tubular epithelial cells under chronic hypoxiaInfluential work since 2022
3. Read the landmark paper: Circular CPM promotes chemoresistance of gastric cancer via activating PRKAA2‐mediated autophagyCited 65 times
4. Go sideways: PRKAG3A closely related topic
5. Go sideways: Protein kinase, AMP-activated, alpha 1A closely related topic

🏆 Landmark papers (most cited)

• Circular CPM promotes chemoresistance of gastric cancer via activating PRKAA2‐mediated autophagy

  Lang Fang, Jialun Lv, Zhe Xuan · 2022 · Clinical and Translational Medicine · 65 citations

• PRKAA2, MTOR, and TFEB in the regulation of lysosomal damage response and autophagy

  Mohd Shariq, Mohammad Firoz Khan, Reshmi Raj · 2024 · Journal of Molecular Medicine · 44 citations

• AMP-kinase α2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol in normal women

  N J Spencer-Jones, D Ge, H Snieder · 2006 · Journal of Medical Genetics · 36 citations

• Single nucleotide polymorphisms in genes encoding LKB1 (STK11), TORC2 (CRTC2) and AMPK α2-subunit (PRKAA2) and risk of type 2 diabetes

  Parvaneh Keshavarz, Hiroshi Inoue, Naoto Nakamura · 2008 · Molecular Genetics and Metabolism · 35 citations

• Haplotype Structures and Large-Scale Association Testing of the 5′ AMP-Activated Protein Kinase Genes PRKAA2, PRKAB1, and PRKAB2 With Type 2 Diabetes

  Maria W. Sun, Jennifer Y. Lee, Paul I.W. de Bakker · 2006 · Diabetes · 27 citations

• ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing Prkaa2 mRNA

  Honglin Liu, Zhenyu Han, Liru Chen · 2024 · JCI Insight · 24 citations

• <p>miR-4999-5p Predicts Colorectal Cancer Survival Outcome and Reprograms Glucose Metabolism by Targeting PRKAA2</p>

  Qiwei Zhang, Zhi Hong, Jieyao Zhu · 2020 · OncoTargets and Therapy · 23 citations

• Effect of different iodine levels on the DNA methylation of PRKAA2, ITGA6, THEM4 and PRL genes in PI3K-AKT signaling pathway and population-based validation from autoimmune thyroiditis patients

  Bingxuan Ren, Siyuan Wan, Huaiyong Wu · 2022 · European Journal of Nutrition · 16 citations

🆕 Influential since 2022

• PRKAA2-mediated mitophagy regulates oxygen consumption in yak renal tubular epithelial cells under chronic hypoxia

  Xuefeng Bai, Hongqin Lu, Yan Cui · 2024 · Cellular Signalling · 10 citations

• CircCDC6 restrains tumor growth and glycolysis energy metabolism in colorectal cancer via regulating miR-3187-3p and downstream PRKAA2

  Chunxiang Zhao, Hong Chen, Kai Min · 2022 · Journal of Bioenergetics and Biomembranes · 9 citations

• Association Analysis of PRKAA2 and MSMB Polymorphisms and Growth Traits of Xiangsu Hybrid Pigs

  Jiali Xu, Yong Ruan, Jinkui Sun · 2022 · Genes · 9 citations

• Phosphorylation of BCL2L13 by PRKAA2/AMPKα2 activates mitophagy in pressure-overloaded heart

  Tomokazu Murakawa, Kinya Otsu · 2025 · Autophagy · 9 citations

• Anti-ferroptotic PRKAA2 serves as a potential diagnostic and prognostic marker for hepatoblastoma

  Yi Xie, Zhongqi Cui, Sijia Fang · 2023 · Journal of Gastrointestinal Oncology · 9 citations

📚 Books worth reading

Open Library didn't respond; try again in a moment.

🔗 Related topics

• PRKAG3 5'-AMP-activated protein kinase subunit gamma-3 is an enzyme that in humans is encoded by the PRKAG3 gene. The protein encoded by this gene is a regulatory…
• Protein kinase, AMP-activated, alpha 1 5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene. The protein encoded by this gene belongs…
• PRKAB2 5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene. The protein encoded by this gene is a regulatory…
• PRKAB1 5'-AMP-activated protein kinase subunit beta-1 is an enzyme that in humans is encoded by the PRKAB1 gene. The protein encoded by this gene is a regulatory…
• PRKAG1 5'-AMP-activated protein kinase subunit gamma-1 is an enzyme that in humans is encoded by the PRKAG1 gene. The protein encoded by this gene is a regulatory…
• PRKAG2 5'-AMP-activated protein kinase subunit gamma-2 is an enzyme that in humans is encoded by the PRKAG2 gene. AMP-activated protein kinase (AMPK) is a heterotrimer…
• AMP-activated protein kinase 5' AMP-activated protein kinase or AMPK or 5' adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular…
• Adenosine monophosphate Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide. AMP consists of a phosphate group, the sugar ribose, and the nucleobase…