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Everything about Neutral mutation
Changes to DNA with no overall impact
Neutral mutations are changes in DNA sequence that are neither beneficial nor detrimental to the ability of an organism to survive and reproduce. In population genetics, mutations in which natural selection does not affect the spread of the mutation in a species are termed neutral mutations. Neutral mutations that are inheritable and not linked to any genes under selection will be lost or will replace all other alleles of the gene. That loss or fixation of the gene proceeds based on random sampling known as genetic drift. A neutral mutation that is in linkage disequilibrium with other alleles that are under selection may proceed to loss or fixation via genetic hitchhiking and/or background selection. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Neutral mutationA 5-minute orientation
- Skim a recent paper: Synonymous mutations in representative yeast genes are mostly strongly non-neutralInfluential work since 2022
- Pick up a classic book: Foundational Papers in Complexity ScienceThe most-reprinted book on the subject
- Read the landmark paper: Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.Cited 10,286 times
- Go sideways: Nonsynonymous substitutionA closely related topic
- Go sideways: History of molecular evolutionA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
Directional mutation pressure and neutral molecular evolution.
PHENOTYPIC EVOLUTION BY NEUTRAL MUTATION
Phenotypic Evolution by Neutral Mutation
Is the evolution of insulin Darwinian or due to selectively neutral mutation?
SHOOT APICAL MERISTEMS AND MUTATION: FIXATION OF SELECTIVELY NEUTRAL CELL GENOTYPES
Expression, functional analysis and mutation of a novel neutral zearalenone-degrading enzyme
Linkage disequilibrium among multiple neutral alleles produced by mutation in finite population
🆕 Influential since 2022
Synonymous mutations in representative yeast genes are mostly strongly non-neutral
Estimation of Neutral Mutation Rates and Quantification of Somatic Variant Selection Using cancereffectsizeR
Natural selection versus neutral mutation in the evolution of subterranean life: A false dichotomy?
Late onset of neutral lipid storage disease due to a rare PNPLA2 mutation in a patient with myopathy and cardiomyopathy
High fraction of silent recombination in a finite-population two-locus neutral birth-death-mutation model
📚 Books worth reading
Foundational Papers in Complexity ScienceDavid Krakauer · 2024
Genetics of populationsPhilip W. Hedrick · 1983
Bioinformatics and Molecular EvolutionPaul G. Higgs · 2009
Population geneticsMatthew B. Hamilton · 2009
Mathematical Statistics Theory and ApplicationsYu. A. Prokhorov, V. V. Sazonov · 2020
Struktur der Kosmos und Menschen. Magie und Esoterik. · 2018
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Nonsynonymous substitution A nonsynonymous substitution is a nucleotide mutation that alters the amino acid sequence of a protein. Nonsynonymous substitutions differ from synonymous…
- History of molecular evolution The history of molecular evolution starts in the early 20th century with "comparative biochemistry", but the field of molecular evolution came into its…
- Synonymous substitution A synonymous substitution (often called a silent substitution though they are not always silent) is the evolutionary substitution of one base for another…
- Neutral theory of molecular evolution The neutral theory of evolution holds that most of the genetic variation within and between species is due to random genetic drift of mutant alleles that…
- The Neutral Theory of Molecular Evolution The Neutral Theory of Molecular Evolution is an influential monograph written in 1983 by Japanese evolutionary biologist Motoo Kimura. While the neutral…
- Ka/Ks ratio In genetics, the Ka/Ks ratio, also known as ω or dN/dS ratio, is used to estimate the balance between neutral mutations, purifying selection and beneficial…
- Molecular evolution Molecular evolution describes how inherited DNA and/or RNA change over evolutionary time, and the consequences of this for proteins and other components…
- Mutation In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Mutations result from…