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Everything about Multiple sequence alignment

Alignment of more than two molecular sequences

Multiple sequence alignment (MSA) is the process or the result of sequence alignment of three or more biological sequences, generally protein, DNA, or RNA. These alignments are used to infer evolutionary relationships via phylogenetic analysis and can highlight homologous features between sequences. Alignments highlight mutation events such as point mutations, insertion mutations and deletion mutations, and alignments are used to assess sequence conservation and infer the presence and activity of protein domains, tertiary structures, secondary structures, and individual amino acids or nucleotides. Wikipedia →

🧭 Start here: a 6-step reading path

  1. Read the overview: Multiple sequence alignmentA 5-minute orientation
  2. Skim a recent paper: ggmsa: a visual exploration tool for multiple sequence alignment and associated dataInfluential work since 2022
  3. Pick up a classic book: C How to ProgramThe most-reprinted book on the subject
  4. Read the landmark paper: CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceCited 52,868 times
  5. Go sideways: T-CoffeeA closely related topic
  6. Go sideways: ClustalA closely related topic

📖 Definitions

No dictionary entry for this exact phrase.

🗂️ The subject at a glance

  1. Problem statement
  2. Graphing approach
  3. Alignment methods
  4. Optimization
  5. Alignment visualization and quality control
  6. Phylogenetic use

🏆 Landmark papers (most cited)

🆕 Influential since 2022

📚 Books worth reading

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics