Everything about M1

🧭 Start here: a 6-step reading path

1. Read the overview: M1A 5-minute orientation
2. Skim a recent paper: Microglia Polarization From M1 to M2 in Neurodegenerative DiseasesInfluential work since 2022
3. Pick up a classic book: The PrinceThe most-reprinted book on the subject
4. Read the landmark paper: The M1 and M2 paradigm of macrophage activation: time for reassessmentCited 4,029 times
5. Go sideways: M3A closely related topic
6. Go sideways: M2A closely related topic

🏆 Landmark papers (most cited)

• The M1 and M2 paradigm of macrophage activation: time for reassessment

  Fernando O. Martinez, Siamon Gordon · 2014 · F1000Prime Reports · 4,029 citations

• Macrophage M1/M2 polarization

  Chen Yunna, Hu Mengru, Wang Lei · 2020 · European Journal of Pharmacology · 2,400 citations

• Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

  Yu Tang, Weidong Le · 2015 · Molecular Neurobiology · 1,984 citations

• Microglial M1/M2 polarization and metabolic states

  Ruben Orihuela, Christopher A McPherson, Gaylia Jean Harry · 2015 · British Journal of Pharmacology · 1,974 citations

• Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

  Marco Orecchioni, Yanal Ghosheh, Akula Bala Pramod · 2019 · Frontiers in Immunology · 1,952 citations

• From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

  Paola Italiani, Diana Boraschi · 2014 · Frontiers in Immunology · 1,891 citations

• A polarizing question: do M1 and M2 microglia exist?

  Richard M Ransohoff · 2016 · Nature Neuroscience · 1,494 citations

• Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

  Eleni Vergadi, Eleftheria Ieronymaki, Konstantina Lyroni · 2017 · The Journal of Immunology · 1,094 citations

🆕 Influential since 2022

• Microglia Polarization From M1 to M2 in Neurodegenerative Diseases

  Shenrui Guo, Hui Wang, Yafu Yin · 2022 · Frontiers in Aging Neuroscience · 938 citations

• M1/M2 macrophages and their overlaps – myth or reality?

  Zuzana Strizova, Iva Benesova, Robin Bartolini · 2023 · Clinical Science · 676 citations

• The Role of M1/M2 Macrophage Polarization in Rheumatoid Arthritis Synovitis

  Maurizio Cutolo, Rosanna Campitiello, Emanuele Gotelli · 2022 · Frontiers in Immunology · 639 citations

• Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing

  Xiaopei Hao, Zhiying Zheng, Hanyuan Liu · 2022 · Redox Biology · 318 citations

• A second-generation M1-polarized CAR macrophage with antitumor efficacy

  Anhua Lei, Hua Yu, Shan Lu · 2023 · Nature Immunology · 309 citations

📚 Books worth reading

• The PrinceNiccolò Machiavelli · 1515
• EssaisMontaigne, Michel de · 1600
• The Crying of Lot 49Thomas Pynchon, Antonio-Prometeo Moya · 1965
• The Emperor of All MaladiesSiddhartha Mukherjee, Nessa Carey · 2010
• CathedralDavid Macaulay · 1973
• 📕Ordnance maintenanceUnited States Department of War · 1940
• The Laws of SimplicityJohn Maeda · 2006
• Foundations of sensation and perceptionGeorge Mather · 2009

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

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