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Everything about KCNN4
Protein-coding gene in the species Homo sapiens
Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the KCa3.1 protein. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: KCNN4A 5-minute orientation
- Skim a recent paper: KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activationInfluential work since 2022
- Read the landmark paper: The Ca2+-Activated K+ChannelKCNN4/KCa3.1 Contributes to Microglia Activation and Nitric Oxide-Dependent NeurodegenerationCited 198 times
- Go sideways: KCNMB2A closely related topic
- Go sideways: KCNU1A closely related topic
🏆 Landmark papers (most cited)
The Ca2+-Activated K+ChannelKCNN4/KCa3.1 Contributes to Microglia Activation and Nitric Oxide-Dependent Neurodegeneration
GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca 2+ signalling in a GABA-independent manner
Physiological Roles of the Intermediate Conductance, Ca2+-activated Potassium Channel Kcnn4
The hSK4 (KCNN4) isoform is the Ca 2 + -activated K + channel (Gardos channel) in human red blood cells
Mutations in the Gardos channel (KCNN4) are associated with hereditary xerocytosis
Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner
Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice
Abolition of Ca2+‐mediated intestinal anion secretion and increased stool dehydration in mice lacking the intermediate conductance Ca2+‐dependent K+ channel Kcnn4
🆕 Influential since 2022
KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation
KCNN4 Promotes the Stemness Potentials of Liver Cancer Stem Cells by Enhancing Glucose Metabolism
KCNN4 may weaken anti-tumor immune response via raising Tregs and diminishing resting mast cells in clear cell renal cell carcinoma
KCNN4 is a Potential Biomarker for Predicting Cancer Prognosis and an Essential Molecule that Remodels Various Components in the Tumor Microenvironment: A Pan-Cancer Study
New KCNN4 Variants Associated With Anemia: Stomatocytosis Without Erythrocyte Dehydration
📚 Books worth reading
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🔗 Related topics
- KCNMB2 Calcium-activated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNMB2 gene. Big Potassium (BK) channels are large conductance…
- KCNU1 Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the KCa5.1 protein. Although this channel is structurally related to…
- KCNN3 SK3 (small conductance calcium-activated potassium channel 3) also known as KCa2.3 is a protein that in humans is encoded by the KCNN3 gene. SK3 is a small-cond…
- KCNN2 Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, also known as KCNN2, is a protein which in humans is encoded…
- KCNMB4 Calcium-activated potassium channel subunit beta-4 is a protein that in humans is encoded by the KCNMB4 gene. MaxiK channels are large conductance, voltage…
- KCNMB3 Calcium-activated potassium channel subunit beta-3 is a protein that in humans is encoded by the KCNMB3 gene. MaxiK channels are large conductance, voltage…
- CLCA1 Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene. This gene encodes a member of the calcium sensitive chloride conductance…
- KCNQ5 Potassium voltage-gated channel subfamily KQT member 5 is a protein that in humans is encoded by the KCNQ5 gene. This gene is a member of the KCNQ potassium…