Everything about IL

🧭 Start here: a 6-step reading path

1. Read the overview: ILA 5-minute orientation
2. Skim a recent paper: IL-17 and IL-17-producing cells in protection versus pathologyInfluential work since 2022
3. Pick up a classic book: The Island of Dr. MoreauThe most-reprinted book on the subject
4. Read the landmark paper: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesCited 5,136 times
5. Go sideways: SUA closely related topic
6. Go sideways: ElA closely related topic

🏆 Landmark papers (most cited)

• Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

  S Sakaguchi, N Sakaguchi, M Asano · 1995 · The Journal of Immunology · 5,136 citations

• The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

  Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou · 2006 · Cell · 4,703 citations

• IL-6 in Inflammation, Immunity, and Disease

  T. Tanaka, M. Narazaki, T. Kishimoto · 2014 · Cold Spring Harbor Perspectives in Biology · 4,589 citations

• IL-17 and Th17 Cells

  Thomas Korn, Estelle Bettelli, Mohamed Oukka · 2009 · Annual Review of Immunology · 4,447 citations

• Succinate is an inflammatory signal that induces IL-1β through HIF-1α

  G. M. Tannahill, A. M. Curtis, J. Adamik · 2013 · Nature · 4,182 citations

• IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

  Claire L. Langrish, Yi Chen, Wendy M. Blumenschein · 2005 · The Journal of Experimental Medicine · 3,369 citations

• IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

  Jochen Schmitz, Alexander Owyang, Elizabeth Oldham · 2005 · Immunity · 3,251 citations

• TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

  Marc Veldhoen, Richard J. Hocking, Christopher J. Atkins · 2006 · Immunity · 3,073 citations

🆕 Influential since 2022

• IL-17 and IL-17-producing cells in protection versus pathology

  Kingston H. G. Mills · 2022 · Nature Reviews Immunology · 1,022 citations

• The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions

  Valentina Carlini, Douglas M. Noonan, Eslam Abdalalem · 2023 · Frontiers in Immunology · 568 citations

• IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines

  Siri Tahtinen, Ann-Jay Tong, Patricia Himmels · 2022 · Nature Immunology · 537 citations

• Targeting IL-6 trans-signalling: past, present and future prospects

  Stefan Rose-John, Brendan J. Jenkins, Christoph Garbers · 2023 · Nature Reviews Immunology · 517 citations

• The role of IL-6/JAK2/STAT3 signaling pathway in cancers

  Bei Huang, Xiaoling Lang, Xihong Li · 2022 · Frontiers in Oncology · 498 citations

📚 Books worth reading

• The Island of Dr. MoreauH. G. Wells · 1896
• The Madman and the PirateRobert Michael Ballantyne · 1883
• South Wind - Norman DouglasNorman Douglas, Norman Douglas · 1900
• Schweizerische RobinsonJohann David Wyss · 1828
• PapillonHenri Charrière · 1969
• The structure and distribution of coral reefsCharles Darwin · 1842
• Kensuke's kingdomMichael Morpurgo · 1999
• Peter and the StarcatchersDave Barry, Ridley Pearson · 2004

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

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