Everything about Grating-coupled interferometry
Grating-coupled interferometry (GCI) is a biophysical characterization method mainly used in biochemistry and drug discovery for label-free analysis of molecular interactions. Similar to other optical methods such as surface plasmon resonance (SPR) or bio-layer interferometry (BLI), it is based on measuring refractive index changes within an evanescent field near a sensor surface. After immobilizing a target to the sensor surface, analyte molecules in solution which bind to that target cause a small increase in local refractive index. By monitoring these refractive changes over time characteristics such as kinetic rates and affinity constants of the analyte-target binding, or analyte concentrations, can be determined. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Grating-coupled interferometryA 5-minute orientation
- Pick up a classic book: Fiber-optic sensors for biomedical applicationsThe most-reprinted book on the subject
- Read the landmark paper: Single beam grating coupled interferometry: high resolution miniaturized label-free sensor for plate based parallel screeningCited 59 times
- Go sideways: Single colour reflectometryA closely related topic
- Go sideways: Dual-polarization interferometryA closely related topic
📖 Definitions
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🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Single beam grating coupled interferometry: high resolution miniaturized label-free sensor for plate based parallel screening
Grating coupled interferometry for optical sensing
Label-free optical monitoring of surface adhesion of extracellular vesicles by grating coupled interferometry
Grating-coupled interferometry reveals binding kinetics and affinities of Ni ions to genetically engineered protein layers
Grating coupled optical waveguide interferometry combined with in situ spectroscopic ellipsometry to monitor surface processes in aqueous solutions
Thermodynamic profiling and fragment screening of GPCRs using grating-coupled interferometry
📚 Books worth reading
- 📕Fiber-optic sensors for biomedical applicationsDaniele Tosi · 2018
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Single colour reflectometry Single colour reflectometry (SCORE), formerly known as imaging Reflectometric Interferometry (iRIf) and 1-lambda Reflectometry, is a physical method based…
- Dual-polarization interferometry Dual-polarization interferometry (DPI) is an analytical technique that probes molecular layers adsorbed to the surface of a waveguide using the evanescent…
- Surface plasmon resonance microscopy Surface plasmon resonance microscopy (SPRM), also called surface plasmon resonance imaging (SPRI), is a label free analytical tool that combines the surface…
- Surface plasmon resonance Surface plasmon resonance (SPR) is a phenomenon that occurs where electrons in a thin metal sheet become excited by light that is directed to the sheet…
- Waveguide (optics) An optical waveguide is a physical structure that guides electromagnetic waves in the optical spectrum. Common types of optical waveguides include optical…
- Evanescent field In electromagnetics, an evanescent field, or evanescent wave, is an oscillating electric and/or magnetic field that does not propagate as an electromagnetic…
- Fiber Bragg grating A fiber Bragg grating (FBG) is a type of distributed Bragg reflector constructed in a short segment of optical fiber that reflects particular wavelengths…
- Phase-contrast X-ray imaging Phase-contrast X-ray imaging or phase-sensitive X-ray imaging is a general term for different technical methods that use information concerning changes…