Everything about GAS5

🧭 Start here: a 6-step reading path

1. Read the overview: GAS5A 5-minute orientation
2. Skim a recent paper: Ginsenoside Rg1 Reduced Microglial Activation and Mitochondrial Dysfunction to Alleviate Depression-Like Behaviour Via the GAS5/EZH2/SOCS3/NRF2 AxisInfluential work since 2022
3. Pick up a classic book: The Boy in the Striped PyjamasThe most-reprinted book on the subject
4. Read the landmark paper: Noncoding RNA Gas5 Is a Growth Arrest– and Starvation-Associated Repressor of the Glucocorticoid ReceptorCited 937 times
5. Go sideways: Small nucleolar RNA SNORD50A closely related topic
6. Go sideways: Small nucleolar RNA SNORD75A closely related topic

🏆 Landmark papers (most cited)

• Noncoding RNA Gas5 Is a Growth Arrest– and Starvation-Associated Repressor of the Glucocorticoid Receptor

  Tomoshige Kino, Darrell E. Hurt, Takamasa Ichijo · 2010 · Science Signaling · 937 citations

• GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer

  M Mourtada-Maarabouni, M R Pickard, V L Hedge · 2008 · Oncogene · 676 citations

• Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3

  Wen Ni, Su Yao, Yunxia Zhou · 2019 · Molecular Cancer · 507 citations

• Classification of gas5 as a Multi-Small-Nucleolar-RNA (snoRNA) Host Gene and a Member of the 5′-Terminal Oligopyrimidine Gene Family Reveals Common Features of snoRNA Host Genes

  Christine M. Smith, Joan A. Steitz · 1998 · Molecular and Cellular Biology · 400 citations

• Negative regulation of lncRNA GAS5 by miR-21

  Z Zhang, Z Zhu, K Watabe · 2013 · Cell Death & Differentiation · 369 citations

• Long non-coding RNA GAS5 regulates apoptosis in prostate cancer cell lines

  M.R. Pickard, M. Mourtada-Maarabouni, G.T. Williams · 2013 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 278 citations

• Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer

  Ming Sun, Fei-yan Jin, Rui Xia · 2014 · BMC Cancer · 249 citations

• Exosomal lncRNA GAS5 regulates the apoptosis of macrophages and vascular endothelial cells in atherosclerosis

  Lei Chen, Wenjin Yang, Yijun Guo · 2017 · PLOS ONE · 234 citations

🆕 Influential since 2022

• Ginsenoside Rg1 Reduced Microglial Activation and Mitochondrial Dysfunction to Alleviate Depression-Like Behaviour Via the GAS5/EZH2/SOCS3/NRF2 Axis

  Junnan Li, Wei Gao, Zhonghui Zhao · 2022 · Molecular Neurobiology · 83 citations

• METTL3 boosts mitochondrial fission and induces cardiac fibrosis by enhancing LncRNA GAS5 methylation

  Bin Tu, Kai Song, Yang Zhou · 2023 · Pharmacological Research · 74 citations

• GAS5 protects against nonalcoholic fatty liver disease via miR-28a-5p/MARCH7/NLRP3 axis-mediated pyroptosis

  Tianxing Chen, Yao Meng, Zhihang Zhou · 2023 · Cell Death & Differentiation · 71 citations

• Research Progress of Long Non-Coding RNA GAS5 in Malignant Tumors

  Guohong Lin, Tianzhun Wu, Xing Gao · 2022 · Frontiers in Oncology · 45 citations

• NAT10-mediated upregulation of GAS5 facilitates immune cell infiltration in non-small cell lung cancer via the MYBBP1A-p53/IRF1/type I interferon signaling axis

  Zimu Wang, Jing Luo, Hairong Huang · 2024 · Cell Death Discovery · 38 citations

📚 Books worth reading

• The Boy in the Striped PyjamasJohn Boyne · 2006
• 📕Public-private competitionsUnited States. General Accounting Office · 1998
• 📕Public-private competitionsUnited States. General Accounting Office · 1998
• Health care and poor relief in 18th and 19th century northern EuropeOle Peter Grell, Cunningham, Andrew Dr · 2002
• Climate Change 2007M. L. Parry · 2007
• Eu Competition and Internal Market Law in the Healthcare SectorLeigh Hancher · 2013

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• Small nucleolar RNA SNORD50 In molecular biology, snoRNA U50 (also known as SNORD50) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear…
• Small nucleolar RNA SNORD75 In molecular biology, Small Nucleolar RNA SNORD75 (also known as U75) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification)…
• Small nucleolar RNA SNORD79 In molecular biology, snoRNA U79 (also known as SNORD79 or Z22) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small…
• Small nucleolar RNA SNORD24 In molecular biology, U24 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. C/D box snoRNAs have been shown…
• Small nucleolar RNA SNORD29 In molecular biology, SNORD29 (also known as U29) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs…
• Small nucleolar RNA host gene 1 Small nucleolar RNA host gene 1 is a non-protein coding RNA that in humans is encoded by the SNHG1 gene. This locus represents a small nucleolar RNA host…
• Small nucleolar RNA SNORD81 In molecular biology, U81 (also sometimes called Z23 snoRNA) is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs…
• Small nucleolar RNA SNORD36 In molecular biology, snoRNA U36 (also known as SNORD36) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other…