Everything about FRA

🧭 Start here: a 6-step reading path

1. Read the overview: FRAA 5-minute orientation
2. Skim a recent paper: The Fra-1/AP-1 Oncoprotein: From the “Undruggable” Transcription Factor to Therapeutic TargetingInfluential work since 2022
3. Pick up a classic book: AngelicoThe most-reprinted book on the subject
4. Read the landmark paper: Glutamate receptor agonists increase the expression of Fos, Fra, and AP‐1 DNA binding activity in the mammalian brainCited 285 times
5. Go sideways: FREA closely related topic
6. Go sideways: ARBA closely related topic

🏆 Landmark papers (most cited)

• Glutamate receptor agonists increase the expression of Fos, Fra, and AP‐1 DNA binding activity in the mammalian brain

  J. L. Sonnenberg, C. Mitchelmore, P. F. Macgregor‐Leon · 1989 · Journal of Neuroscience Research · 285 citations

• Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1

  Wolfram Jochum, Jean-Pierre David, Candace Elliott · 2000 · Nature Medicine · 279 citations

• fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen.

  D R Cohen, T Curran · 1988 · Molecular and Cellular Biology · 222 citations

• The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes.

  D R Cohen, P C Ferreira, R Gentz · 1989 · Genes & Development · 220 citations

• The fra(X) syndrome: Neurological, electrophysiological, and neuropathological abnormalities

  K. E. Wisniewski, S. M. Segan, C. M. Miezejeski · 1991 · American Journal of Medical Genetics · 208 citations

• Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages

  Qingshan Wang, Hong Ni, Lan Lan · 2010 · Cell Research · 204 citations

• Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1

  Robert Eferl, Peter Hasselblatt, Martina Rath · 2008 · Proceedings of the National Academy of Sciences · 197 citations

• MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1

  S Yang, Y Li, J Gao · 2012 · Oncogene · 194 citations

🆕 Influential since 2022

• The Fra-1/AP-1 Oncoprotein: From the “Undruggable” Transcription Factor to Therapeutic Targeting

  Laura Casalino, Francesco Talotta, Amelia Cimmino · 2022 · Cancers · 60 citations

• FRA-1 as a Regulator of EMT and Metastasis in Breast Cancer

  Laura Casalino, Francesco Talotta, Ilenia Matino · 2023 · International Journal of Molecular Sciences · 47 citations

• A systematic review on the performance of fracture risk assessment tools: FRAX, DeFRA, FRA-HS

  G. Adami, A. Biffi, G. Porcu · 2023 · Journal of Endocrinological Investigation · 43 citations

• Enhanced detection of power transformer winding faults through 3D FRA signatures and image processing techniques

  Xiaozhen Zhao, Ge Wu, Dingqian Yang · 2025 · Electric Power Systems Research · 41 citations

• Role of Fra-2 in cancer

  Gian Luca Rampioni Vinciguerra, Marina Capece, Giorgia Scafetta · 2023 · Cell Death & Differentiation · 37 citations

📚 Books worth reading

• AngelicoSir John Wyndham Pope-Hennessy · 1932
• Fra AngelicoSir John Wyndham Pope-Hennessy · 1952
• Fra Bartolommeo: Master Draughtsman of the High RenaissanceChris Fischer · 1990
• Fra Filippo LippiJeffrey Ruda · 1993
• Fra AngelicoLaurence B. Kanter · 2005
• Filippo LippiGloria Fossi · 1989
• Fra AngelicoGermain Bazin · 1949
• Foreign governments and their backgroundsJohn Clarke Adams · 1950

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

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