Everything about Ext2

🧭 Start here: a 6-step reading path

1. Read the overview: Ext2A 5-minute orientation
2. Skim a recent paper: Structure of the human heparan sulfate polymerase complex EXT1-EXT2Influential work since 2022
3. Pick up a classic book: Foreign Trade by Commodities - 1999 EditionThe most-reprinted book on the subject
4. Read the landmark paper: The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfateCited 412 times
5. Go sideways: Ext4A closely related topic
6. Go sideways: Ext3A closely related topic

🏆 Landmark papers (most cited)

• The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

  Craig McCormick, Gillian Duncan, K. Tina Goutsos · 2000 · Proceedings of the National Academy of Sciences · 412 citations

• The Putative Tumor Suppressors EXT1 and EXT2 Are Glycosyltransferases Required for the Biosynthesis of Heparan Sulfate

  Thomas Lind, Frank Tufaro, Craig McCormick · 1998 · Journal of Biological Chemistry · 377 citations

• The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes

  Dominique Stickens, Gregory Clines, David Burbee · 1996 · Nature Genetics · 287 citations

• Mice deficient in Ext2 lack heparan sulfate and develop exostoses

  Dominique Stickens, Beverly M. Zak, Nathalie Rougier · 2005 · Development · 222 citations

• Contribution of EXT1, EXT2, and EXTL3 to Heparan Sulfate Chain Elongation

  Marta Busse, Almir Feta, Jenny Presto · 2007 · Journal of Biological Chemistry · 203 citations

• Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

  Jenny Presto, Maria Thuveson, Pernilla Carlsson · 2008 · Proceedings of the National Academy of Sciences · 167 citations

• Mutations in the EXT1 and EXT2 Genes in Hereditary Multiple Exostoses

  Wim Wuyts, Wim Van Hul, Kristel De Boulle · 1998 · The American Journal of Human Genetics · 167 citations

• Molecular basis of multiple exostoses: mutations in the EXT1 and EXT2 genes

  Wim Wuyts, Wim Van Hul · 2000 · Human Mutation · 163 citations

🆕 Influential since 2022

• Structure of the human heparan sulfate polymerase complex EXT1-EXT2

  Francisco Leisico, Juneina Omeiri, Christine Le Narvor · 2022 · Nature Communications · 54 citations

• A novel role of exostosin glycosyltransferase 2 (EXT2) in glioblastoma cell metabolism, radiosensitivity and ferroptosis

  Rocío Matesanz-Sánchez, Mirko Peitzsch, Inga Lange · 2025 · Cell Death & Differentiation · 13 citations

• Insights into the Peritumoural Brain Zone of Glioblastoma: CDK4 and EXT2 May Be Potential Drivers of Malignancy

  Martina Giambra, Andrea Di Cristofori, Donatella Conconi · 2023 · International Journal of Molecular Sciences · 10 citations

• EXT2: a novel prognostic and predictive biomarker for head and neck squamous cell carcinoma

  Angel Jenifer Arul Selvan, Balachander Kannan, Chandra Pandi · 2024 · Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology · 8 citations

• Mutations in the heparan sulfate backbone elongating enzymes EXT1 and EXT2 have no major effect on endothelial glycocalyx and the glomerular filtration barrier

  Ramzi Khalil, Margien G. S. Boels, PALGA Group · 2022 · Molecular Genetics and Genomics · 6 citations

📚 Books worth reading

• 📕Foreign Trade by Commodities - 1999 EditionOrganisation for Economic Co-operation and Development · 1999
• 📕Gannat bussameG. J. Reinink · 1988
• 📕Die Geschichte des Lebna-Dengel, Claudius, und MināsManfred Kropp · 1988
• 📕Little Monsters Literacy Pack 2Ransom Publishing Ransom · 2005
• File system forensic analysisBrian Carrier · 2005
• 📕Vie de Georges de SaglāGérard Colin · 1987
• 📕Little Monsters Numeracy Pack 2Ransom Publishing Ransom · 2005
• 📕The faith of the Unctionists in the Ethiopian ChurchGetatchew Haile · 1990

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

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