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Everything about Prostaglandin EP3 receptor
Protein found in humans
Prostaglandin EP3 receptor (EP3, 53kDa), is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the human gene PTGER3; it is one of four identified EP receptors, the others being EP1, EP2, and EP4, all of which bind with and mediate cellular responses to PGE2 and also, but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). EP has been implicated in various physiological and pathological responses. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: Prostaglandin EP3 receptorA 5-minute orientation
- Skim a recent paper: Prostaglandin EP3 receptor–expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signalingInfluential work since 2022
- Pick up a classic book: Born to flyThe most-reprinted book on the subject
- Read the landmark paper: Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3Cited 550 times
- Go sideways: Prostaglandin EP4 receptorA closely related topic
- Go sideways: Prostaglandin EP2 receptorA closely related topic
📖 Definitions
No dictionary entry for this exact phrase.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3
Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity
The Role of Prostaglandin E Receptor Subtypes (EP1, EP2, EP3, and EP4) in Bone Resorption: An Analysis Using Specific Agonists for the Respective EPs
Cloning and expression of a cDNA for mouse prostaglandin E receptor EP3 subtype.
EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses
Host Prostaglandin E2-EP3 Signaling Regulates Tumor-Associated Angiogenesis and Tumor Growth
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3
Two isoforms of the EP3 receptor with different carboxyl-terminal domains. Identical ligand binding properties and different coupling properties with Gi proteins.
🆕 Influential since 2022
Prostaglandin EP3 receptor–expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling
EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model
PGE2‐EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase
Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex
Inhibition of Prostaglandin E2 Receptor EP3 Attenuates Oxidative Stress and Neuronal Apoptosis Partially by Modulating p38MAPK/FOXO3/Mul1/Mfn2 Pathway after Subarachnoid Hemorrhage in Rats
📚 Books worth reading
Born to flyShane Osborn · 2001
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
🔗 Related topics
- Prostaglandin EP4 receptor Prostaglandin E2 receptor 4 (EP4) is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the PTGER4 gene in humans. It is one of four identified…
- Prostaglandin EP2 receptor Prostaglandin E2 receptor 2, also known as EP2, is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the human gene PTGER2: it is one of…
- Prostaglandin EP1 receptor Prostaglandin E2 receptor 1 (EP1) is a 42kDa prostaglandin receptor encoded by the PTGER1 gene. EP1 is one of four identified EP receptors, EP1, EP2, EP3…
- Sulprostone Sulprostone is an analogue of prostaglandin E2 (PGE2) that has oxytocic activity in assays of rat kidney cells and tissues. There are four known receptors…
- Eicosanoid receptor Most of the eicosanoid receptors are integral membrane protein G protein-coupled receptors (GPCRs) that bind and respond to eicosanoid signaling molecules…
- Prostaglandin F receptor Prostaglandin F receptor (FP) is a receptor belonging to the prostaglandin (PG) group of receptors. FP binds to and mediates the biological actions of…
- Prostaglandin E2 Prostaglandin E2 (PGE2), also known as dinoprostone, is a naturally occurring prostaglandin with oxytocic properties that is used as a medication. Dinoprostone…
- Thromboxane receptor The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the TBXA2R gene, The thromboxane receptor…