Everything about E4

🧭 Start here: a 6-step reading path

1. Read the overview: E4A 5-minute orientation
2. Skim a recent paper: Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucomaInfluential work since 2022
3. Pick up a classic book: Little WomenThe most-reprinted book on the subject
4. Read the landmark paper: Information Provided on Humic Substances by E4/E6 RatiosCited 918 times
5. Go sideways: E1A closely related topic
6. Go sideways: E6A closely related topic

🏆 Landmark papers (most cited)

• Information Provided on Humic Substances by E4/E6 Ratios

  Y. Chen, N. Senesi, M. Schnitzer · 1977 · Soil Science Society of America Journal · 918 citations

• A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly

  Manfred Koegl, Thorsten Hoppe, Stephan Schlenker · 1999 · Cell · 888 citations

• Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease

  Robert W. Mahley, Karl H. Weisgraber, Yadong Huang · 2006 · Proceedings of the National Academy of Sciences · 748 citations

• Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

  B. P. Nathan, S. Bellosta, D. A. Sanan · 1994 · Science · 632 citations

• Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

  Matthew R Halliday, Sanket V Rege, Qingyi Ma · 2015 · Journal of Cerebral Blood Flow & Metabolism · 614 citations

• Serum Total Cholesterol, Apolipoprotein E {FC12}e4 Allele, and Alzheimer’s Disease

  Irma-Leena Notkola, Raimo Sulkava, Juha Pekkanen · 1998 · Neuroepidemiology · 526 citations

• Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease.

  J Poirier, M C Delisle, R Quirion · 1995 · Proceedings of the National Academy of Sciences · 415 citations

• Leukotriene E4 and granulocytic infiltration into asthmatic airways

  L.A Laitinen, T Haahtela, V Vilkka · 1993 · The Lancet · 405 citations

🆕 Influential since 2022

• Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma

  Milica A. Margeta, Zhuoran Yin, Charlotte Madore · 2022 · Immunity · 123 citations

• APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes

  Sherida M. de Leeuw, Aron W.T. Kirschner, Karina Lindner · 2022 · Stem Cell Reports · 119 citations

• A Method for Stress Detection Using Empatica E4 Bracelet and Machine-Learning Techniques

  Sara Campanella, Ayham Altaleb, Alberto Belli · 2023 · Sensors · 102 citations

• Wearable Technologies for Electrodermal and Cardiac Activity Measurements: A Comparison between Fitbit Sense, Empatica E4 and Shimmer GSR3+

  Vincenzo Ronca, Ana C. Martinez-Levy, Alessia Vozzi · 2023 · Sensors · 61 citations

• Association of a wide range of chronic diseases and apolipoprotein E4 genotype with subsequent risk of dementia in community-dwelling adults: A retrospective cohort study

  Xianwen Shang, Zhuoting Zhu, Xueli Zhang · 2022 · eClinicalMedicine · 60 citations

📚 Books worth reading

• Little WomenLouisa May Alcott · 1848
• The Old Man and the SeaErnest Hemingway · 1952
• HeidiSpyri, Johanna · 1885
• Guess How Much I Love YouSam McBratney, Anita Jeram · 1994
• Max ErnstMax Ernst, Werner Spies · 1956
• BelovedToni Morrison · 1987
• A People and a NationMary Beth Norton · 1982
• SapiensYuval Noah Harari · 2011

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

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