Everything about D2

🧭 Start here: a 6-step reading path

1. Read the overview: D2A 5-minute orientation
2. Skim a recent paper: Antipsychotic dose, dopamine D2 receptor occupancy and extrapyramidal side-effects: a systematic review and dose-response meta-analysisInfluential work since 2022
3. Pick up a classic book: Twelfth Night, or What You WillThe most-reprinted book on the subject
4. Read the landmark paper: Trajectory Surface Hopping Approach to Nonadiabatic Molecular Collisions: The Reaction of H+ with D2Cited 1,558 times
5. Go sideways: D3A closely related topic
6. Go sideways: D1A closely related topic

🏆 Landmark papers (most cited)

• Trajectory Surface Hopping Approach to Nonadiabatic Molecular Collisions: The Reaction of H+ with D2

  John C. Tully, Richard K. Preston · 1971 · The Journal of Chemical Physics · 1,558 citations

• Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial

  Yung-Jue Bang, Young-Woo Kim, Han-Kwang Yang · 2012 · The Lancet · 1,429 citations

• Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats

  Paul M Johnson, Paul J Kenny · 2010 · Nature Neuroscience · 1,241 citations

• Positron Emission Tomographic Analysis of Central D1 and D2 Dopamine Receptor Occupancy in Patients Treated With Classical Neuroleptics and Clozapine

  Lars Farde · 1992 · Archives of General Psychiatry · 1,111 citations

• Patient survival after D1 and D2 resections for gastric cancer: long-term results of the MRC randomized surgical trial

  for the Surgical Co-operative Group, A Cuschieri, S Weeden · 1999 · British Journal of Cancer · 1,062 citations

• D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons

  D. James Surmeier, Jun Ding, Michelle Day · 2007 · Trends in Neurosciences · 1,058 citations

• Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

  Ellen Y. T. Chien, Wei Liu, Qiang Zhao · 2010 · Science · 1,055 citations

• Nucleus Accumbens D2/3 Receptors Predict Trait Impulsivity and Cocaine Reinforcement

  Jeffrey W. Dalley, Tim D. Fryer, Laurent Brichard · 2007 · Science · 1,018 citations

🆕 Influential since 2022

• Antipsychotic dose, dopamine D2 receptor occupancy and extrapyramidal side-effects: a systematic review and dose-response meta-analysis

  Spyridon Siafis, Hui Wu, Dongfang Wang · 2023 · Molecular Psychiatry · 168 citations

• Adjuvant nivolumab plus chemotherapy versus placebo plus chemotherapy for stage III gastric or gastro-oesophageal junction cancer after gastrectomy with D2 or more extensive lymph-node dissection (ATTRACTION-5): a randomised, multicentre, double-blind, placebo-controlled, phase 3 trial

  Yoon-Koo Kang, Masanori Terashima, Young-Woo Kim · 2024 · The Lancet Gastroenterology & Hepatology · 104 citations

• Dopamine receptor D2 antagonism normalizes profibrotic macrophage-endothelial crosstalk in non-alcoholic steatohepatitis

  Jie Qing, Yafeng Ren, Yuwei Zhang · 2022 · Journal of Hepatology · 103 citations

• Cerebellar dopamine D2 receptors regulate social behaviors

  Laura Cutando, Emma Puighermanal, Laia Castell · 2022 · Nature Neuroscience · 94 citations

• D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning

  Jennifer E. Zachry, Munir Gunes Kutlu, Hye Jean Yoon · 2024 · Neuron · 88 citations

📚 Books worth reading

• Twelfth Night, or What You WillWilliam Shakespeare · 1734
• Ab urbe conditaTitus Livius · 1481
• MetamorphosesOvid · 1479
• Le Morte d'ArthurThomas Malory · 1557
• Ars AmatoriaOvid, Niklas Holzberg · 1494
• De bello judaicoFlavius Josephus · 1481
• The preludeWilliam Wordsworth · 1850
• PunicaTiberius Catius Silius Italicus · 1516

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

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