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Everything about Cosegregation
Transmission of multiple close together genes
Cosegregation, in genealogy, refers to the tendency of two or more genes located close together on the same chromosome to be inherited together during cell division. Due to their physical proximity, these genes are considered genetically linked and are likely to be inherited together. Wikipedia →
🧭 Start here: a 6-step reading path
- Read the overview: CosegregationA 5-minute orientation
- Skim a recent paper: Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematodeInfluential work since 2022
- Pick up a classic book: Stem cells in regenerative medicineThe most-reprinted book on the subject
- Read the landmark paper: Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a FamilyCited 625 times
- Go sideways: Genome architecture mappingA closely related topic
- Go sideways: Biological networkA closely related topic
📖 Definitions
Noun The transmission of two or more linked genes on a chromosome to the same daughter cell leading to the inheritance by the offspring of these genes together.
🗂️ The subject at a glance
🏆 Landmark papers (most cited)
Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family
Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells
Consideration of Cosegregation in the Pathogenicity Classification of Genomic Variants
Polo-like kinase Cdc5 promotes chiasmata formation and cosegregation of sister centromeres at meiosis I
Cytoplasmic transfer of the mtDNA nt 8993 T-->G (ATP6) point mutation associated with Leigh syndrome into mtDNA-less cells demonstrates cosegregation with a decrease in state III respiration and ADP/O ratio.
Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt–sensitive rats
Hepatocyte Nuclear Factor-1α Gene Inactivation: Cosegregation between Liver Adenomatosis and Diabetes Phenotypes in Two Maturity-Onset Diabetes of the Young (MODY)3 Families
Cosegregation of missense mutations of the luteinizing hormone receptor gene with familial male-limited precocious puberty
🆕 Influential since 2022
Cosegregation of recombinant chromatids maintains genome-wide heterozygosity in an asexual nematode
Dissecting the cosegregation probability from genome architecture mapping
shinyseg: a web application for flexible cosegregation and sensitivity analysis
Exploring the influence of cosegregation on mechanical properties of Mg { 10 1 ¯ 1 } twin boundaries: A first-principles investigation
Association between missense variants of uncertain significance in the CHEK2 gene and hereditary breast cancer: a cosegregation and bioinformatics analysis
📚 Books worth reading
Stem cells in regenerative medicineJulie Audet · 2009
Stem cells in regenerative medicine · 2009
Ranked by number of editions on Open Library, a rough measure of how lasting a book is.
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