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Everything about Cell-based models

Mathematical models representing biological cells

Cell-based models are mathematical models that represent biological cells as discrete entities. Within the field of computational biology they are often simply called agent-based models of which they are a specific application and they are used for simulating the biomechanics of multicellular structures such as tissues. to study the influence of these behaviors on how tissues are organised in time and space. Their main advantage is the easy integration of cell level processes such as cell division, intracellular processes and single-cell variability within a cell population. Wikipedia →

🧭 Start here: a 6-step reading path

  1. Read the overview: Cell-based modelsA 5-minute orientation
  2. Skim a recent paper: Trophoblast stem cell-based organoid models of the human placental barrierInfluential work since 2022
  3. Pick up a classic book: Stem cells and tissue repairThe most-reprinted book on the subject
  4. Read the landmark paper: Screening out irrelevant cell-based models of diseaseCited 521 times
  5. Go sideways: List of systems biology modeling softwareA closely related topic
  6. Go sideways: LibroadrunnerA closely related topic

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🗂️ The subject at a glance

  1. Model types
  2. Applications
  3. Simulation frameworks

🏆 Landmark papers (most cited)

🆕 Influential since 2022

📚 Books worth reading

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