Everything about Backbone One

🧭 Start here: a 6-step reading path

1. Read the overview: Backbone OneA 5-minute orientation
2. Skim a recent paper: U-KAN Makes Strong Backbone for Medical Image Segmentation and GenerationInfluential work since 2022
3. Pick up a classic book: TelecommunicationsThe most-reprinted book on the subject
4. Read the landmark paper: ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SBCited 11,008 times
5. Go sideways: Backbone LabsA closely related topic
6. Go sideways: Xbox Cloud GamingA closely related topic

🏆 Landmark papers (most cited)

• ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

  James A. Maier, Carmenza Martinez, Koushik Kasavajhala · 2015 · Journal of Chemical Theory and Computation · 11,008 citations

• Comparison of multiple Amber force fields and development of improved protein backbone parameters

  Viktor Hornak, Robert Abel, Asim Okur · 2006 · Proteins: Structure, Function, and Bioinformatics · 6,728 citations

• Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ 1 and χ 2 Dihedral Angles

  Robert B. Best, Xiao Zhu, Jihyun Shim · 2012 · Journal of Chemical Theory and Computation · 4,812 citations

• Extending the treatment of backbone energetics in protein force fields: Limitations of gas‐phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

  Alexander D. Mackerell, Michael Feig, Charles L. Brooks · 2004 · Journal of Computational Chemistry · 3,236 citations

• Res2Net: A New Multi-Scale Backbone Architecture

  Shang-Hua Gao, Ming-Ming Cheng, Kai Zhao · 2021 · IEEE Transactions on Pattern Analysis and Machine Intelligence · 3,006 citations

• Protein backbone angle restraints from searching a database for chemical shift and sequence homology

  Gabriel Cornilescu, Frank Delaglio, Ad Bax · 1999 · Journal of Biomolecular NMR · 2,802 citations

• ff19SB: Amino-Acid-Specific Protein Backbone Parameters Trained against Quantum Mechanics Energy Surfaces in Solution

  Chuan Tian, Koushik Kasavajhala, Kellon A. A. Belfon · 2019 · Journal of Chemical Theory and Computation · 2,687 citations

• TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

  Yang Shen, Frank Delaglio, Gabriel Cornilescu · 2009 · Journal of Biomolecular NMR · 2,507 citations

🆕 Influential since 2022

• U-KAN Makes Strong Backbone for Medical Image Segmentation and Generation

  Chenxin Li, Xinyu Liu, Wuyang Li · 2025 · Proceedings of the AAAI Conference on Artificial Intelligence · 335 citations

• Breast Cancer Detection on Histopathological Images Using a Composite Dilated Backbone Network

  Vinodkumar Mohanakurup, Syam Machinathu Parambil Gangadharan, Pallavi Goel · 2022 · Computational Intelligence and Neuroscience · 251 citations

• Design Principles for High-Temperature Superconductors with a Hydrogen-Based Alloy Backbone at Moderate Pressure

  Zihan Zhang, Tian Cui, Michael J. Hutcheon · 2022 · Physical Review Letters · 240 citations

• LSKNet: A Foundation Lightweight Backbone for Remote Sensing

  Yuxuan Li, Xiang Li, Yimain Dai · 2024 · International Journal of Computer Vision · 227 citations

📚 Books worth reading

• 📕TelecommunicationsUnited States. General Accounting Office · 1988
• American To The Backbone The Life Of James Wc Pennington The Fugitive Slave Who Became One Of The First Black AbolitionistsChristopher L. Webber · 2011
• BackboneCarol Bly · 1984
• 📕BackboneKaren Duffy · 2017
• Before the BackboneH. Gee · 2007
• Clever backboneJohn Agard · 2009
• The backbone of EnglandAndrew Bibby · 2008
• War on Small BusinessRoth Carol · 2021

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

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