Everything about ATP

🧭 Start here: a 6-step reading path

1. Read the overview: ATPA 5-minute orientation
2. Skim a recent paper: Cellular ATP demand creates metabolically distinct subpopulations of mitochondriaInfluential work since 2022
3. Pick up a classic book: BiochemistryThe most-reprinted book on the subject
4. Read the landmark paper: Multidrug resistance in cancer: role of ATP–dependent transportersCited 4,789 times
5. Go sideways: ATBA closely related topic
6. Go sideways: ATSA closely related topic

🏆 Landmark papers (most cited)

• Multidrug resistance in cancer: role of ATP–dependent transporters

  Michael M. Gottesman, Tito Fojo, Susan E. Bates · 2002 · Nature Reviews Cancer · 4,789 citations

• Distantly related sequences in the alpha‐ and beta‐subunits of ATP synthase, myosin, kinases and other ATP‐requiring enzymes and a common nucleotide binding fold.

  J.E. Walker, M. Saraste, M.J. Runswick · 1982 · The EMBO Journal · 4,452 citations

• ATP mediates rapid microglial response to local brain injury in vivo

  Dimitrios Davalos, Jaime Grutzendler, Guang Yang · 2005 · Nature Neuroscience · 3,562 citations

• Cryopyrin activates the inflammasome in response to toxins and ATP

  Sanjeev Mariathasan, David S. Weiss, Kim Newton · 2006 · Nature · 2,714 citations

• Calcium, ATP, and ROS: a mitochondrial love-hate triangle

  Paul S. Brookes, Yisang Yoon, James L. Robotham · 2004 · American Journal of Physiology-Cell Physiology · 2,290 citations

• ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

  Kathryn E. Wellen, Georgia Hatzivassiliou, Uma M. Sachdeva · 2009 · Science · 2,210 citations

• A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis

  Koen Andries, Peter Verhasselt, Jerome Guillemont · 2005 · Science · 1,992 citations

• The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

  Cai-Hong Yun, Kristen E. Mengwasser, Angela V. Toms · 2008 · Proceedings of the National Academy of Sciences · 1,846 citations

🆕 Influential since 2022

• Cellular ATP demand creates metabolically distinct subpopulations of mitochondria

  Keun Woo Ryu, Tak Shun Fung, Daphne C. Baker · 2024 · Nature · 315 citations

• Slow TCA flux and ATP production in primary solid tumours but not metastases

  Caroline R. Bartman, Daniel R. Weilandt, Yihui Shen · 2023 · Nature · 315 citations

• The role of bacterial ATP-binding cassette (ABC) transporters in pathogenesis and virulence: Therapeutic and vaccine potential

  Armaan A. Akhtar, David PJ. Turner · 2022 · Microbial Pathogenesis · 222 citations

• A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo

  Zhaofa Wu, Kaikai He, Yue Chen · 2022 · Neuron · 218 citations

• Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia

  Marisa R. Morrow, Battsetseg Batchuluun, Jianhan Wu · 2022 · Cell Metabolism · 204 citations

📚 Books worth reading

• BiochemistryLubert Stryer, Jeremy Mark Berg · 1975
• Heat shock proteins and cytoprotectionAlexander E. Kabakov, Vladimir L. Gabai · 1996
• ABC transporters and multidrug resistanceJacques Robert · 2009
• Rafael NadalTom Oldfield · 2009
• ABC proteinsI. B. Holland · 2002
• Atp TourRichard Evans · 1991
• ABC transportersMichael M. Gottesman · 1998
• The CircuitRowan Ricardo Phillips · 2018

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

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