Everything about APR

🧭 Start here: a 6-step reading path

1. Read the overview: APRA 5-minute orientation
2. Skim a recent paper: APR-246 triggers ferritinophagy and ferroptosis of diffuse large B-cell lymphoma cells with distinct TP53 mutationsInfluential work since 2022
3. Pick up a classic book: Lost HorizonThe most-reprinted book on the subject
4. Read the landmark paper: Tissue factor and hemostasis [published erratum appears in Blood 1988 Apr;71(4):1178]Cited 688 times
5. Go sideways: Pressurized water reactorA closely related topic
6. Go sideways: ATRA closely related topic

🏆 Landmark papers (most cited)

• Tissue factor and hemostasis [published erratum appears in Blood 1988 Apr;71(4):1178]

  Y Nemerson · 1988 · Blood · 688 citations

• Eprenetapopt (APR-246) and Azacitidine in TP53 -Mutant Myelodysplastic Syndromes

  David A. Sallman, Amy E. DeZern, Guillermo Garcia-Manero · 2021 · Journal of Clinical Oncology · 472 citations

• Levels of emotional awareness: a cognitive-developmental theory and its application to psychopathology [published erratum appears in Am J Psychiatry 1987 Apr;144(4):542]

  · 1987 · American Journal of Psychiatry · 432 citations

• Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

  Sören Lehmann, Vladimir J.N. Bykov, Dina Ali · 2012 · Journal of Clinical Oncology · 375 citations

• LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr) and an enhancer of exotoxin A expression

  M J Gambello, S Kaye, B H Iglewski · 1993 · Infection and Immunity · 324 citations

• The generation of a colE1-Apr cloning vehicle which allows detection of inserted DNA

  Magdalene So, Ron Gill, Stanley Falkow · 1975 · Molecular and General Genetics MGG · 238 citations

• APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

  Qiang Zhang, Vladimir J. N. Bykov, Klas G. Wiman · 2018 · Cell Death & Disease · 237 citations

• An activator/repressor dual system allows tight tetracycline-regulated gene expression in budding yeast [published erratum appears in Nucleic Acids Res 1998 Apr 1;26(7):following 1855]

  G Belli · 1998 · Nucleic Acids Research · 229 citations

🆕 Influential since 2022

• APR-246 triggers ferritinophagy and ferroptosis of diffuse large B-cell lymphoma cells with distinct TP53 mutations

  Yuheng Hong, Tianyuan Ren, Xiaoxuan Wang · 2022 · Leukemia · 58 citations

• The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

  Zilu Wang, Huimin Hu, Luuk Heitink · 2023 · Cell Death & Differentiation · 52 citations

• Phase Ib study of eprenetapopt (APR-246) in combination with pembrolizumab in patients with advanced or metastatic solid tumors

  H. Park, G.I. Shapiro, X. Gao · 2022 · ESMO Open · 49 citations

• Chromium-Coated Zirconium Cladding Neutronics Impact for APR-1400 Reactor Core

  Mohammad Alrwashdeh, Saeed A. Alameri · 2022 · Energies · 42 citations

• All Patient Refined-Diagnosis Related Groups’ (APR-DRGs) Severity of Illness and Risk of Mortality as predictors of in-hospital mortality

  João Vasco Santos, João Viana, Carla Pinto · 2022 · Journal of Medical Systems · 39 citations

📚 Books worth reading

• Lost HorizonJames Hilton · 1933
• Life of PiYann Martel · 2000
• Schweizerische RobinsonJohann David Wyss · 1828
• The Ugly AmericanWilliam J. Lederer, Eugene Burdick · 1958
• The Satanic VersesSalman Rushdie · 1988
• Relato de un náufragoGabriel García Márquez · 1970
• Alive!Piers Paul Read · 1920
• Vendredi ou les Limbes du Pacifique (Folio Series Number 959)Michel Tournier · 1967

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

🔗 Related topics

• Pressurized water reactor A pressurized water reactor (PWR) is a type of light-water nuclear reactor. PWRs are the most common type of nuclear power reactor, representing almost…
• ATR ATR may refer to: Acute transfusion reaction Ataxia telangiectasia and Rad3 related, a protein involved in DNA damage repair Advanced Test Reactor, nuclear…
• IPWR-900 The Indian Pressurized Water Reactor-900 (IPWR-900) is a class of pressurized water reactors being designed by the Bhabha Atomic Research Centre (BARC)…
• MSR Look up MSR in Wiktionary, the free dictionary. MSR may refer to: Macrophage scavenger receptor, a receptor found in macrophages Magnetic stripe reader…
• Nuclear power in South Korea Hanbit Hanul Shin Hanul Kori Shin Kori Saeul Wolseong Shin Wolseong Cheonji Nuclear power is a major power source in South Korea, providing 30% of the…
• ART Look up ART in Wiktionary, the free dictionary. ART may refer to: American Refrigerator Transit Company Arab Radio and Television Network ART Teenz American…
• AMR Look up amr in Wiktionary, the free dictionary. Amr or AMR may refer to: Antimicrobial resistance, of microorganisms (bacteria, viruses, parasites) to…
• Scram A scram or SCRAM is an emergency shutdown of a nuclear reactor effected by terminating the fission reaction. It is also the name that is given to the manually…