Everything about A2

🧭 Start here: a 6-step reading path

1. Read the overview: A2A 5-minute orientation
2. Skim a recent paper: The Phospholipase A2 Superfamily: Structure, Isozymes, Catalysis, Physiologic and Pathologic RolesInfluential work since 2022
3. Pick up a classic book: MacbethThe most-reprinted book on the subject
4. Read the landmark paper: Structure of the human class I histocompatibility antigen, HLA-A2Cited 2,665 times
5. Go sideways: A3A closely related topic
6. Go sideways: B2A closely related topic

🏆 Landmark papers (most cited)

• Structure of the human class I histocompatibility antigen, HLA-A2

  P. J. Bjorkman, M. A. Saper, B. Samraoui · 1987 · Nature · 2,665 citations

• Diversity of group types, regulation, and function of phospholipase A2.

  E.A. Dennis · 1994 · Journal of Biological Chemistry · 1,177 citations

• Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

  David N. Garboczi, Partho Ghosh, Ursula Utz · 1996 · Nature · 1,141 citations

• The expanding superfamily of phospholipase A2 enzymes: classification and characterization

  David A Six, Edward A Dennis · 2000 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 1,099 citations

• Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains.

  K C Parker, M A Bednarek, J E Coligan · 1994 · The Journal of Immunology · 1,075 citations

• Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolution

  M.A. Saper, P.J. Bjorkman, D.C. Wiley · 1991 · Journal of Molecular Biology · 841 citations

• Phospholipase A2 structure/function, mechanism, and signaling

  John E. Burke, Edward A. Dennis · 2009 · Journal of Lipid Research · 817 citations

• Identification, Cloning, Expression, and Purification of Three Novel Human Calcium-independent Phospholipase A2 Family Members Possessing Triacylglycerol Lipase and Acylglycerol Transacylase Activities

  Christopher M. Jenkins, David J. Mancuso, Wei Yan · 2004 · Journal of Biological Chemistry · 766 citations

🆕 Influential since 2022

• The Phospholipase A2 Superfamily: Structure, Isozymes, Catalysis, Physiologic and Pathologic Roles

  Shibbir Ahmed Khan, Marc A. Ilies · 2023 · International Journal of Molecular Sciences · 220 citations

• Cytosolic phospholipase A2 in infiltrating monocyte derived macrophages does not impair recovery after spinal cord injury in female mice

  Ethan P. Glaser, Timothy J. Kopper, William M. Bailey · 2025 · Scientific Reports · 191 citations

• Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy

  Paul M Ridker, Nader Rifai, Jean MacFadyen · 2022 · Circulation · 129 citations

• Integrative phosphatidylcholine metabolism through phospholipase A2 in rats with chronic kidney disease

  Yan-ni Wang, Zhi-hao Zhang, Hong-jiao Liu · 2022 · Acta Pharmacologica Sinica · 115 citations

• The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism

  Mihee Oh, Seo Young Jang, Ji-Yoon Lee · 2023 · Nature Communications · 106 citations

📚 Books worth reading

• MacbethWilliam Shakespeare · 1508
• ἸλιάςὍμηρος · 1505
• ὈδύσσειαὍμηρος · 1488
• The TempestWilliam Shakespeare · 1611
• Two Gentlemen of VeronaWilliam Shakespeare · 1632
• Twelfth Night, or What You WillWilliam Shakespeare · 1734
• Henry VWilliam Shakespeare · 1600
• MetamorphosesOvid · 1479

Ranked by number of editions on Open Library, a rough measure of how lasting a book is.

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